The Murine Model of Mucopolysaccharidosis IIIB Develops Cardiopathies over Time Leading to Heart Failure

Mucopolysaccharidosis (MPS) IIIB is a lysosomal disease due to the deficiency of the enzyme α-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation. The disease is characterized by mild somatic features and severe neurological disorders. Very little is known on the cardiac dy...

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Detalles Bibliográficos
Autores principales: Schiattarella, Gabriele Giacomo, Cerulo, Giuliana, De Pasquale, Valeria, Cocchiaro, Pasquale, Paciello, Orlando, Avallone, Luigi, Belfiore, Maria Paola, Iacobellis, Francesca, Di Napoli, Daniele, Magliulo, Fabio, Perrino, Cinzia, Trimarco, Bruno, Esposito, Giovanni, Di Natale, Paola, Pavone, Luigi Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493027/
https://www.ncbi.nlm.nih.gov/pubmed/26147524
http://dx.doi.org/10.1371/journal.pone.0131662

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