Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences

Computational protein design has found great success in engineering proteins for thermodynamic stability, binding specificity, or enzymatic activity in a ‘single state’ design (SSD) paradigm. Multi-specificity design (MSD), on the other hand, involves considering the stability of multiple protein st...

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Detalles Bibliográficos
Autores principales: Sevy, Alexander M., Jacobs, Tim M., Crowe, James E., Meiler, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493036/
https://www.ncbi.nlm.nih.gov/pubmed/26147100
http://dx.doi.org/10.1371/journal.pcbi.1004300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493036/
https://www.ncbi.nlm.nih.gov/pubmed/26147100
http://dx.doi.org/10.1371/journal.pcbi.1004300

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