Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene

Age of onset (AO) of Huntington disease (HD) is mainly determined by the length of the CAG repeat expansion (CAGexp) in exon 1 of the HTT gene. Additional genetic variation has been suggested to contribute to AO, although the mechanism by which it could affect AO is presently unknown. The aim of thi...

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Detalles Bibliográficos
Autores principales: Valcárcel-Ocete, Leire, Alkorta-Aranburu, Gorka, Iriondo, Mikel, Fullaondo, Asier, García-Barcina, María, Fernández-García, José Manuel, Lezcano-García, Elena, Losada-Domingo, José María, Ruiz-Ojeda, Javier, Álvarez de Arcaya, Amaia, Pérez-Ramos, José María, Roos, Raymund A. C., Nielsen, Jørgen E., Saft, Carsten, Zubiaga, Ana M., Aguirre, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493078/
https://www.ncbi.nlm.nih.gov/pubmed/26148071
http://dx.doi.org/10.1371/journal.pone.0131573

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