Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in IL-1/LPS-Insufflated Rats

BACKGROUND: Glutamine (GLN) attenuates acute lung injury (ALI) but its effect on alveolar macrophages is unknown. We hypothesized that GLN pretreatment would induce the anti-inflammatory CD163/heme oxygenase (HO)-1/p38-MAPK dephosphorylation pathway in alveolar macrophages and reduce ALI in rats ins...

Descripción completa

Detalles Bibliográficos
Autores principales: Fernandez-Bustamante, Ana, Agazio, Amanda, Wilson, Paul, Elkins, Nancy, Domaleski, Luke, He, Qianbin, Baer, Kaily A., Moss, Angela F. D., Wischmeyer, Paul E., Repine, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493112/
https://www.ncbi.nlm.nih.gov/pubmed/26147379
http://dx.doi.org/10.1371/journal.pone.0130764

Ejemplares similares

Ejemplares similares