A highlight from the LUPUS 2014 meeting: eight great ideas

This review describes eight ‘great ideas’ regarding bench-to-bedside considerations in systemic lupus erythematosus (SLE) presented at the second international LUPUS meeting in Quebec, September 2014. The topics included: correcting the impaired clearance of apoptotic fragments; optimisation of clin...

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Detalles Bibliográficos
Autores principales: Buyon, Jill P, Cohen, Phillip, Merrill, Joan T, Gilkeson, Gary, Kaplan, Mariana, James, Judith, McCune, W Joseph, Bernatsky, Sasha, Elkon, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493165/
https://www.ncbi.nlm.nih.gov/pubmed/26167290
http://dx.doi.org/10.1136/lupus-2015-000087
Descripción
Sumario:This review describes eight ‘great ideas’ regarding bench-to-bedside considerations in systemic lupus erythematosus (SLE) presented at the second international LUPUS meeting in Quebec, September 2014. The topics included: correcting the impaired clearance of apoptotic fragments; optimisation of clinical trial design: the PERFECT (Pre Evaluation Reducing Frighteningly Elevated Coverable Targets) study; lipidomics and metabolomics in SLE; importance of the inflammasome; identification and treatment of asymptomatic autoimmunity: prevention of SLE; combining low doses of hydroxychloroquine and quinacrine for long-term maintenance therapy of SLE; reducing emergency room visits and the critical relevance of the autoantigen.

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