Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway

The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4(DCAF1). Numerous mutations of Merlin have been identified in Neurofibromatosis type 2 and other cancer patients. Despite more than two decades of r...

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Detalles Bibliográficos
Autores principales: Li, Youjun, Zhou, Hao, Li, Fengzhi, Chan, Siew Wee, Lin, Zhijie, Wei, Zhiyi, Yang, Zhou, Guo, Fusheng, Lim, Chun Jye, Xing, Wancai, Shen, Yuequan, Hong, Wanjin, Long, Jiafu, Zhang, Mingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493278/
https://www.ncbi.nlm.nih.gov/pubmed/26045165
http://dx.doi.org/10.1038/cr.2015.69

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