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Can we omit prophylactic inguinal nodal irradiation in anal cancer patients?
PURPOSE: To evaluate the appropriateness of prophylactic inguinal nodal irradiation (PINI), we analyzed patterns of failure in anal cancer patients who were inguinal node-negative at presentation and did not receive PINI. MATERIALS AND METHODS: We retrospectively reviewed the records of 33 anal canc...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Radiation Oncology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493432/ https://www.ncbi.nlm.nih.gov/pubmed/26157677 http://dx.doi.org/10.3857/roj.2015.33.2.83 |
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author | Kim, Hakyoung Park, Hee Chul Yu, Jeong Il Choi, Doo Ho Ahn, Yong Chan Kim, Seung Tae Park, Joon Oh Park, Young Suk Kim, Hee Cheol |
author_facet | Kim, Hakyoung Park, Hee Chul Yu, Jeong Il Choi, Doo Ho Ahn, Yong Chan Kim, Seung Tae Park, Joon Oh Park, Young Suk Kim, Hee Cheol |
author_sort | Kim, Hakyoung |
collection | PubMed |
description | PURPOSE: To evaluate the appropriateness of prophylactic inguinal nodal irradiation (PINI), we analyzed patterns of failure in anal cancer patients who were inguinal node-negative at presentation and did not receive PINI. MATERIALS AND METHODS: We retrospectively reviewed the records of 33 anal cancer patients treated by definitive concurrent chemoradiation therapy (CCRT) between 1994 and 2013. Radiotherapy consisted of a total dose of 44-45 Gy (22-25 fractions in 5 weeks) on the whole pelvis, anus, and perineum. Except inguinal lymphadenopathy was present at initial diagnosis, the entire inguinal chain was not included in the radiation field. In other words, there was no PINI. RESULTS: The median follow-up duration was 50 months (range, 4 to 218 months). Median survival and progression-free survival (PFS) were 57 months (range, 10 to 218 months) and 50 months (range, 4 to 218 months), respectively. Among the survival, the median follow-up duration was 51 months (range, 12 to 218 months). The 5-year overall survival and PFS rates were 93.4% and 88.8%, respectively. Although none of the patients received inguinal node irradiation for prophylactic purposes, there was no inguinal recurrence. CONCLUSION: Treatment of anal cancer by omitting PINI might be considered in selected patients with clinically uninvolved inguinal nodes. |
format | Online Article Text |
id | pubmed-4493432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Society for Radiation Oncology |
record_format | MEDLINE/PubMed |
spelling | pubmed-44934322015-07-08 Can we omit prophylactic inguinal nodal irradiation in anal cancer patients? Kim, Hakyoung Park, Hee Chul Yu, Jeong Il Choi, Doo Ho Ahn, Yong Chan Kim, Seung Tae Park, Joon Oh Park, Young Suk Kim, Hee Cheol Radiat Oncol J Original Article PURPOSE: To evaluate the appropriateness of prophylactic inguinal nodal irradiation (PINI), we analyzed patterns of failure in anal cancer patients who were inguinal node-negative at presentation and did not receive PINI. MATERIALS AND METHODS: We retrospectively reviewed the records of 33 anal cancer patients treated by definitive concurrent chemoradiation therapy (CCRT) between 1994 and 2013. Radiotherapy consisted of a total dose of 44-45 Gy (22-25 fractions in 5 weeks) on the whole pelvis, anus, and perineum. Except inguinal lymphadenopathy was present at initial diagnosis, the entire inguinal chain was not included in the radiation field. In other words, there was no PINI. RESULTS: The median follow-up duration was 50 months (range, 4 to 218 months). Median survival and progression-free survival (PFS) were 57 months (range, 10 to 218 months) and 50 months (range, 4 to 218 months), respectively. Among the survival, the median follow-up duration was 51 months (range, 12 to 218 months). The 5-year overall survival and PFS rates were 93.4% and 88.8%, respectively. Although none of the patients received inguinal node irradiation for prophylactic purposes, there was no inguinal recurrence. CONCLUSION: Treatment of anal cancer by omitting PINI might be considered in selected patients with clinically uninvolved inguinal nodes. The Korean Society for Radiation Oncology 2015-06 2015-06-30 /pmc/articles/PMC4493432/ /pubmed/26157677 http://dx.doi.org/10.3857/roj.2015.33.2.83 Text en Copyright © 2015. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Hakyoung Park, Hee Chul Yu, Jeong Il Choi, Doo Ho Ahn, Yong Chan Kim, Seung Tae Park, Joon Oh Park, Young Suk Kim, Hee Cheol Can we omit prophylactic inguinal nodal irradiation in anal cancer patients? |
title | Can we omit prophylactic inguinal nodal irradiation in anal cancer patients? |
title_full | Can we omit prophylactic inguinal nodal irradiation in anal cancer patients? |
title_fullStr | Can we omit prophylactic inguinal nodal irradiation in anal cancer patients? |
title_full_unstemmed | Can we omit prophylactic inguinal nodal irradiation in anal cancer patients? |
title_short | Can we omit prophylactic inguinal nodal irradiation in anal cancer patients? |
title_sort | can we omit prophylactic inguinal nodal irradiation in anal cancer patients? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493432/ https://www.ncbi.nlm.nih.gov/pubmed/26157677 http://dx.doi.org/10.3857/roj.2015.33.2.83 |
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