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Clinical outcome of fiducial-less CyberKnife radiosurgery for stage I non-small cell lung cancer

PURPOSE: To evaluate the treatment results in early stage non-small cell lung cancer patients who have undergone fiducial-less CyberKnife radiosurgery (CKRS). MATERIALS AND METHODS: From June 2011 to November 2013, 58 patients underwent CKRS at Asan Medical Center for stage I lung cancer. After excl...

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Autores principales: Jung, In-Hye, Song, Si Yeol, Jung, Jinhong, Cho, Byungchul, Kwak, Jungwon, Je, Hyoung Uk, Choi, Wonsik, Jung, Nuri Hyun, Kim, Su Ssan, Choi, Eun Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Radiation Oncology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493433/
https://www.ncbi.nlm.nih.gov/pubmed/26157678
http://dx.doi.org/10.3857/roj.2015.33.2.89
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author Jung, In-Hye
Song, Si Yeol
Jung, Jinhong
Cho, Byungchul
Kwak, Jungwon
Je, Hyoung Uk
Choi, Wonsik
Jung, Nuri Hyun
Kim, Su Ssan
Choi, Eun Kyung
author_facet Jung, In-Hye
Song, Si Yeol
Jung, Jinhong
Cho, Byungchul
Kwak, Jungwon
Je, Hyoung Uk
Choi, Wonsik
Jung, Nuri Hyun
Kim, Su Ssan
Choi, Eun Kyung
author_sort Jung, In-Hye
collection PubMed
description PURPOSE: To evaluate the treatment results in early stage non-small cell lung cancer patients who have undergone fiducial-less CyberKnife radiosurgery (CKRS). MATERIALS AND METHODS: From June 2011 to November 2013, 58 patients underwent CKRS at Asan Medical Center for stage I lung cancer. After excluding 14 patients, we retrospectively reviewed the records of the remaining 44 patients. All analyses were performed using SPSS ver. 21. RESULTS: The median age at diagnosis was 75 years. Most patients had inoperable primary lung cancer with a poor pulmonary function test with comorbidity or old age. The clinical stage was IA in 30 patients (68.2%), IB in 14 (31.8%). The mean tumor size was 2.6 cm (range, 1.2 to 4.8 cm), and the tumor was smaller than 2 cm in 12 patients (27.3%). The radiation dose given was 48-60 Gy in 3-4 fractions. In a median follow-up of 23.1 months, local recurrence occurred in three patients (2-year local recurrence-free survival rate, 90.4%) and distant metastasis occurred in 13 patients. All patients tolerated the radiosurgery well, only two patients developing grade 3 dyspnea. The most common complications were radiation-induced fibrosis and pneumonitis. Eight patients died due to cancer progression. CONCLUSION: The results showed that fiducial-less CKRS shows comparable local tumor control and survival rates to those of LINAC-based SABR or CKRS with a fiducial marker. Thus, fiducial-less CKRS using Xsight lung tracking system can be effectively and safely performed for patients with medically inoperable stage I non-small cell lung cancer without any risk of procedure-related complication.
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spelling pubmed-44934332015-07-08 Clinical outcome of fiducial-less CyberKnife radiosurgery for stage I non-small cell lung cancer Jung, In-Hye Song, Si Yeol Jung, Jinhong Cho, Byungchul Kwak, Jungwon Je, Hyoung Uk Choi, Wonsik Jung, Nuri Hyun Kim, Su Ssan Choi, Eun Kyung Radiat Oncol J Original Article PURPOSE: To evaluate the treatment results in early stage non-small cell lung cancer patients who have undergone fiducial-less CyberKnife radiosurgery (CKRS). MATERIALS AND METHODS: From June 2011 to November 2013, 58 patients underwent CKRS at Asan Medical Center for stage I lung cancer. After excluding 14 patients, we retrospectively reviewed the records of the remaining 44 patients. All analyses were performed using SPSS ver. 21. RESULTS: The median age at diagnosis was 75 years. Most patients had inoperable primary lung cancer with a poor pulmonary function test with comorbidity or old age. The clinical stage was IA in 30 patients (68.2%), IB in 14 (31.8%). The mean tumor size was 2.6 cm (range, 1.2 to 4.8 cm), and the tumor was smaller than 2 cm in 12 patients (27.3%). The radiation dose given was 48-60 Gy in 3-4 fractions. In a median follow-up of 23.1 months, local recurrence occurred in three patients (2-year local recurrence-free survival rate, 90.4%) and distant metastasis occurred in 13 patients. All patients tolerated the radiosurgery well, only two patients developing grade 3 dyspnea. The most common complications were radiation-induced fibrosis and pneumonitis. Eight patients died due to cancer progression. CONCLUSION: The results showed that fiducial-less CKRS shows comparable local tumor control and survival rates to those of LINAC-based SABR or CKRS with a fiducial marker. Thus, fiducial-less CKRS using Xsight lung tracking system can be effectively and safely performed for patients with medically inoperable stage I non-small cell lung cancer without any risk of procedure-related complication. The Korean Society for Radiation Oncology 2015-06 2015-06-30 /pmc/articles/PMC4493433/ /pubmed/26157678 http://dx.doi.org/10.3857/roj.2015.33.2.89 Text en Copyright © 2015. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jung, In-Hye
Song, Si Yeol
Jung, Jinhong
Cho, Byungchul
Kwak, Jungwon
Je, Hyoung Uk
Choi, Wonsik
Jung, Nuri Hyun
Kim, Su Ssan
Choi, Eun Kyung
Clinical outcome of fiducial-less CyberKnife radiosurgery for stage I non-small cell lung cancer
title Clinical outcome of fiducial-less CyberKnife radiosurgery for stage I non-small cell lung cancer
title_full Clinical outcome of fiducial-less CyberKnife radiosurgery for stage I non-small cell lung cancer
title_fullStr Clinical outcome of fiducial-less CyberKnife radiosurgery for stage I non-small cell lung cancer
title_full_unstemmed Clinical outcome of fiducial-less CyberKnife radiosurgery for stage I non-small cell lung cancer
title_short Clinical outcome of fiducial-less CyberKnife radiosurgery for stage I non-small cell lung cancer
title_sort clinical outcome of fiducial-less cyberknife radiosurgery for stage i non-small cell lung cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493433/
https://www.ncbi.nlm.nih.gov/pubmed/26157678
http://dx.doi.org/10.3857/roj.2015.33.2.89
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