Cargando…

3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus

Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues. In the present study, we investigated the effects of 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahippocampall...

Descripción completa

Detalles Bibliográficos
Autores principales: Okuyama, Satoshi, Miyoshi, Kazuhiro, Tsumura, Yuichi, Amakura, Yoshiaki, Yoshimura, Morio, Yoshida, Takashi, Nakajima, Mitsunari, Furukawa, Yoshiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493459/
https://www.ncbi.nlm.nih.gov/pubmed/25884208
http://dx.doi.org/10.3390/brainsci5020118
_version_ 1782379919410462720
author Okuyama, Satoshi
Miyoshi, Kazuhiro
Tsumura, Yuichi
Amakura, Yoshiaki
Yoshimura, Morio
Yoshida, Takashi
Nakajima, Mitsunari
Furukawa, Yoshiko
author_facet Okuyama, Satoshi
Miyoshi, Kazuhiro
Tsumura, Yuichi
Amakura, Yoshiaki
Yoshimura, Morio
Yoshida, Takashi
Nakajima, Mitsunari
Furukawa, Yoshiko
author_sort Okuyama, Satoshi
collection PubMed
description Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues. In the present study, we investigated the effects of 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahippocampally with lipopolysaccharide (LPS). We demonstrated that subcutaneously injected HMF suppressed: (1) LPS-induced losses in body weight; (2) LPS-induced microglial activation in the hippocampus; and (3) LPS-induced interleukin-1β mRNA expression in the hippocampus. These results suggest that HMF has the ability to reduce neuroinflammation in the brain.
format Online
Article
Text
id pubmed-4493459
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-44934592015-07-07 3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus Okuyama, Satoshi Miyoshi, Kazuhiro Tsumura, Yuichi Amakura, Yoshiaki Yoshimura, Morio Yoshida, Takashi Nakajima, Mitsunari Furukawa, Yoshiko Brain Sci Communication Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues. In the present study, we investigated the effects of 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahippocampally with lipopolysaccharide (LPS). We demonstrated that subcutaneously injected HMF suppressed: (1) LPS-induced losses in body weight; (2) LPS-induced microglial activation in the hippocampus; and (3) LPS-induced interleukin-1β mRNA expression in the hippocampus. These results suggest that HMF has the ability to reduce neuroinflammation in the brain. MDPI 2015-04-15 /pmc/articles/PMC4493459/ /pubmed/25884208 http://dx.doi.org/10.3390/brainsci5020118 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Okuyama, Satoshi
Miyoshi, Kazuhiro
Tsumura, Yuichi
Amakura, Yoshiaki
Yoshimura, Morio
Yoshida, Takashi
Nakajima, Mitsunari
Furukawa, Yoshiko
3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus
title 3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus
title_full 3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus
title_fullStr 3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus
title_full_unstemmed 3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus
title_short 3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus
title_sort 3,5,6,7,8,3′,4′-heptamethoxyflavone, a citrus polymethoxylated flavone, attenuates inflammation in the mouse hippocampus
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493459/
https://www.ncbi.nlm.nih.gov/pubmed/25884208
http://dx.doi.org/10.3390/brainsci5020118
work_keys_str_mv AT okuyamasatoshi 3567834heptamethoxyflavoneacitruspolymethoxylatedflavoneattenuatesinflammationinthemousehippocampus
AT miyoshikazuhiro 3567834heptamethoxyflavoneacitruspolymethoxylatedflavoneattenuatesinflammationinthemousehippocampus
AT tsumurayuichi 3567834heptamethoxyflavoneacitruspolymethoxylatedflavoneattenuatesinflammationinthemousehippocampus
AT amakurayoshiaki 3567834heptamethoxyflavoneacitruspolymethoxylatedflavoneattenuatesinflammationinthemousehippocampus
AT yoshimuramorio 3567834heptamethoxyflavoneacitruspolymethoxylatedflavoneattenuatesinflammationinthemousehippocampus
AT yoshidatakashi 3567834heptamethoxyflavoneacitruspolymethoxylatedflavoneattenuatesinflammationinthemousehippocampus
AT nakajimamitsunari 3567834heptamethoxyflavoneacitruspolymethoxylatedflavoneattenuatesinflammationinthemousehippocampus
AT furukawayoshiko 3567834heptamethoxyflavoneacitruspolymethoxylatedflavoneattenuatesinflammationinthemousehippocampus