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Computational Modeling to Predict Fatigue Behavior of NiTi Stents: What Do We Need?

NiTi (nickel-titanium) stents are nowadays commonly used for the percutaneous treatment of peripheral arterial disease. However, their effectiveness is still debated in the clinical field. In fact a peculiar cyclic biomechanical environment is created before and after stent implantation, with the ri...

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Autores principales: Dordoni, Elena, Petrini, Lorenza, Wu, Wei, Migliavacca, Francesco, Dubini, Gabriele, Pennati, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493513/
https://www.ncbi.nlm.nih.gov/pubmed/26011245
http://dx.doi.org/10.3390/jfb6020299
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author Dordoni, Elena
Petrini, Lorenza
Wu, Wei
Migliavacca, Francesco
Dubini, Gabriele
Pennati, Giancarlo
author_facet Dordoni, Elena
Petrini, Lorenza
Wu, Wei
Migliavacca, Francesco
Dubini, Gabriele
Pennati, Giancarlo
author_sort Dordoni, Elena
collection PubMed
description NiTi (nickel-titanium) stents are nowadays commonly used for the percutaneous treatment of peripheral arterial disease. However, their effectiveness is still debated in the clinical field. In fact a peculiar cyclic biomechanical environment is created before and after stent implantation, with the risk of device fatigue failure. An accurate study of the device fatigue behavior is of primary importance to ensure a successful stenting procedure. Regulatory authorities recognize the possibility of performing computational analyses instead of experimental tests for the assessment of medical devices. However, confidence in numerical methods is only possible after verification and validation of the models used. For the case of NiTi stents, mechanical properties are strongly dependent on the device dimensions and the whole treatments undergone during manufacturing process. Hence, special attention should be paid to the accuracy of the description of the device geometry and the material properties implementation into the numerical code, as well as to the definition of the fatigue limit. In this paper, a path for setting up an effective numerical model for NiTi stent fatigue assessment is proposed and the results of its application in a specific case study are illustrated.
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spelling pubmed-44935132015-07-07 Computational Modeling to Predict Fatigue Behavior of NiTi Stents: What Do We Need? Dordoni, Elena Petrini, Lorenza Wu, Wei Migliavacca, Francesco Dubini, Gabriele Pennati, Giancarlo J Funct Biomater Article NiTi (nickel-titanium) stents are nowadays commonly used for the percutaneous treatment of peripheral arterial disease. However, their effectiveness is still debated in the clinical field. In fact a peculiar cyclic biomechanical environment is created before and after stent implantation, with the risk of device fatigue failure. An accurate study of the device fatigue behavior is of primary importance to ensure a successful stenting procedure. Regulatory authorities recognize the possibility of performing computational analyses instead of experimental tests for the assessment of medical devices. However, confidence in numerical methods is only possible after verification and validation of the models used. For the case of NiTi stents, mechanical properties are strongly dependent on the device dimensions and the whole treatments undergone during manufacturing process. Hence, special attention should be paid to the accuracy of the description of the device geometry and the material properties implementation into the numerical code, as well as to the definition of the fatigue limit. In this paper, a path for setting up an effective numerical model for NiTi stent fatigue assessment is proposed and the results of its application in a specific case study are illustrated. MDPI 2015-05-20 /pmc/articles/PMC4493513/ /pubmed/26011245 http://dx.doi.org/10.3390/jfb6020299 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dordoni, Elena
Petrini, Lorenza
Wu, Wei
Migliavacca, Francesco
Dubini, Gabriele
Pennati, Giancarlo
Computational Modeling to Predict Fatigue Behavior of NiTi Stents: What Do We Need?
title Computational Modeling to Predict Fatigue Behavior of NiTi Stents: What Do We Need?
title_full Computational Modeling to Predict Fatigue Behavior of NiTi Stents: What Do We Need?
title_fullStr Computational Modeling to Predict Fatigue Behavior of NiTi Stents: What Do We Need?
title_full_unstemmed Computational Modeling to Predict Fatigue Behavior of NiTi Stents: What Do We Need?
title_short Computational Modeling to Predict Fatigue Behavior of NiTi Stents: What Do We Need?
title_sort computational modeling to predict fatigue behavior of niti stents: what do we need?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493513/
https://www.ncbi.nlm.nih.gov/pubmed/26011245
http://dx.doi.org/10.3390/jfb6020299
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