Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18

Serpins generally serve as inhibitors that utilize a mobile reactive center loop (RCL) as bait to trap protease targets. Here, we present the crystal structure of serpin18 from Bombyx mori at 1.65 Å resolution, which has a very short and stable RCL. Activity analysis showed that the inhibitory targe...

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Detalles Bibliográficos
Autores principales: Guo, Peng-Chao, Dong, Zhaoming, Zhao, Ping, Zhang, Yan, He, Huawei, Tan, Xiang, Zhang, Weiwei, Xia, Qingyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493575/
https://www.ncbi.nlm.nih.gov/pubmed/26148664
http://dx.doi.org/10.1038/srep11863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493575/
https://www.ncbi.nlm.nih.gov/pubmed/26148664
http://dx.doi.org/10.1038/srep11863

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