Cargando…

Strategy to enhance efficacy of doxorubicin in solid tumor cells by methyl-β-cyclodextrin: Involvement of p53 and Fas receptor ligand complex

Doxorubicin (DOX) is one of the preferred drugs for treating breast and liver cancers. However, its clinical application is limited due to severe side effects and the accompanying drug resistance. In this context, we investigated the effect on therapeutic efficacy of DOX by cholesterol depleting age...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mohammad, Naoshad, Vikram Singh, Shivendra, Malvi, Parmanand, Chaube, Balkrishna, Athavale, Dipti, Vanuopadath, Muralidharan, Nair, Sudarslal Sadasivan, Nair, Bipin, Bhat, Manoj Kumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493576/ https://www.ncbi.nlm.nih.gov/pubmed/26149967 http://dx.doi.org/10.1038/srep11853

Ejemplares similares

Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance
por: Malvi, Parmanand, et al.
Publicado: (2016)

Cholesterol depletion by methyl-β-cyclodextrin augments tamoxifen induced cell death by enhancing its uptake in melanoma
por: Mohammad, Naoshad, et al.
Publicado: (2014)

Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression
por: Chaube, Balkrishna, et al.
Publicado: (2015)

The Need for Next-Generation Antivenom for Snakebite Envenomation in India
por: Vanuopadath, Muralidharan, et al.
Publicado: (2023)

Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state
por: Malvi, Parmanand, et al.
Publicado: (2018)

Clove Bud Oil Modulates Pathogenicity Phenotypes of the Opportunistic Human Pathogen Pseudomonas aeruginosa
por: Haripriyan, Jayalekshmi, et al.
Publicado: (2018)

Editorial: Cancer metabolism: molecular insights, metabolic crosstalk in the tumor microenvironment, and implications for therapy
por: Chaube, Balkrishna, et al.
Publicado: (2023)

Combination of Repurposed Drug Diosmin with Amoxicillin-Clavulanic acid Causes Synergistic Inhibition of Mycobacterial Growth
por: Pushkaran, Anju Choorakottayil, et al.
Publicado: (2019)

Inherent and Acquired Resistance to Paclitaxel in Hepatocellular Carcinoma: Molecular Events Involved
por: Meena, Avtar Singh, et al.
Publicado: (2013)

Hyaluronan-Cyclodextrin Conjugates as Doxorubicin Delivery Systems
por: Bognanni, Noemi, et al.
Publicado: (2023)

AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesis
por: Chaube, B, et al.
Publicado: (2015)

Hepatocellular carcinoma-associated hypercholesterolemia: involvement of proprotein-convertase-subtilisin-kexin type-9 (PCSK9)
por: Athavale, Dipti, et al.
Publicado: (2018)

Long-term cure of soft tissue sarcoma with pegylated-liposomal doxorubicin after doxorubicin and ifosfamide failure
por: Savani, Malvi, et al.
Publicado: (2019)

Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression
por: Nagarajan, Arvindhan, et al.
Publicado: (2018)

Anaplastic Lymphoma Kinase Confers Resistance to BRAF Kinase Inhibitors in Melanoma
por: Janostiak, Radoslav, et al.
Publicado: (2019)

Proteasomal inhibition sensitizes cervical cancer cells to mitomycin C-induced bystander effect: the role of tumor microenvironment
por: Singh, S V, et al.
Publicado: (2015)

Dissecting the role of RNA modification regulatory proteins in melanoma
por: Malvi, Parmanand, et al.
Publicado: (2019)

Transcriptional, chromatin, and metabolic landscapes of LDHA inhibitor–resistant pancreatic ductal adenocarcinoma
por: Malvi, Parmanand, et al.
Publicado: (2022)

Co-targeting of specific epigenetic regulators in combination with CDC7 potently inhibit melanoma growth
por: Chava, Suresh, et al.
Publicado: (2022)

Understanding Below-replacement Fertility in Kerala, India
por: Nair, P. Sadasivan
Publicado: (2010)

Doxorubicin sensitizes breast cancer cells to natural killer cells in connection with increased Fas receptors
por: Sawasdee, Nunghathai, et al.
Publicado: (2022)

Disruption of the MDM2–p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway
por: Koster, R, et al.
Publicado: (2011)

Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression
por: Malvi, Parmanand, et al.
Publicado: (2019)

N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production
por: Malvi, Parmanand, et al.
Publicado: (2021)

The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability
por: Henkler, Frank, et al.
Publicado: (2005)

Glucose induced activation of canonical Wnt signaling pathway in hepatocellular carcinoma is regulated by DKK4
por: Chouhan, Surbhi, et al.
Publicado: (2016)

Correction: Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells
por: Mayengbam, Shyamananda Singh, et al.
Publicado: (2023)

Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells
por: Mayengbam, Shyamananda Singh, et al.
Publicado: (2023)

Cancer-Related Intracellular Signalling Pathways Activated by DOXorubicin/Cyclodextrin-Graphene-Based Nanomaterials
por: Pennisi, Rosamaria, et al.
Publicado: (2022)

SAPO-1/Fas and sFas-L ratio, level of Bcl-2 and p53 as a predictors of multiple organ dysfunction syndrome in polytrauma
por: Kiseleva, A, et al.
Publicado: (2011)

Tissue Microarray Analysis of Fas and FasL Expressions in Human Non-small Cell Lung Carcinomas; with Reference to the p53 and bcl-2 Overexpressions
por: Myong, Na-Hye
Publicado: (2005)

Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway
por: Potu, Harish, et al.
Publicado: (2014)

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand
Publicado: (1996)

Associations of serum soluble Fas and Fas ligand (FasL) with outcomes in systemic lupus erythematosus
por: Vincent, Fabien B, et al.
Publicado: (2020)

Intracellular Fate and Impact on Gene Expression of Doxorubicin/Cyclodextrin-Graphene Nanomaterials at Sub-Toxic Concentration
por: Caccamo, Daniela, et al.
Publicado: (2020)

Fas receptor (CD95) & Fas ligand (CD178) expression in patients with tobacco-related intraoral squamous cell carcinoma
por: Das, Satya N., et al.
Publicado: (2011)

Neuromuscular Disorders
por: Nair, Muralidharan
Publicado: (2019)

Specimen collection from chest tubes: A novel method
por: Baldi, Milind, et al.
Publicado: (2013)

Hereditary hemorrhagic telangiectasia with hemothorax in pregnancy
por: Raiya, Sagar, et al.
Publicado: (2017)

Understanding the role of Fas-Fas ligand system in bone
por: Marusic, Ana, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_p84fptp70mk53ia67e7c1f8v0j