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Increased RIPK4 expression is associated with progression and poor prognosis in cervical squamous cell carcinoma patients

Aberrant expression of receptor interacting protein kinase 4 (RIPK4), a crucial regulatory protein of Wnt/β-catenin signaling, has recently been reported to be involved in several cancers. Here, we report the potential clinical implication and biological functions of RIPK4 in cervical squamous cell...

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Autores principales: Liu, De-Qing, Li, Fang-Fang, Zhang, Jiang-Bo, Zhou, Tie-Jun, Xue, Wen-Qiong, Zheng, Xiao-Hui, Chen, Yuan-Bin, Liao, Xiao-Yu, Zhang, Lan, Zhang, Shao-Dan, Hu, Ye-Zhu, Jia, Wei-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493702/
https://www.ncbi.nlm.nih.gov/pubmed/26148476
http://dx.doi.org/10.1038/srep11955
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author Liu, De-Qing
Li, Fang-Fang
Zhang, Jiang-Bo
Zhou, Tie-Jun
Xue, Wen-Qiong
Zheng, Xiao-Hui
Chen, Yuan-Bin
Liao, Xiao-Yu
Zhang, Lan
Zhang, Shao-Dan
Hu, Ye-Zhu
Jia, Wei-Hua
author_facet Liu, De-Qing
Li, Fang-Fang
Zhang, Jiang-Bo
Zhou, Tie-Jun
Xue, Wen-Qiong
Zheng, Xiao-Hui
Chen, Yuan-Bin
Liao, Xiao-Yu
Zhang, Lan
Zhang, Shao-Dan
Hu, Ye-Zhu
Jia, Wei-Hua
author_sort Liu, De-Qing
collection PubMed
description Aberrant expression of receptor interacting protein kinase 4 (RIPK4), a crucial regulatory protein of Wnt/β-catenin signaling, has recently been reported to be involved in several cancers. Here, we report the potential clinical implication and biological functions of RIPK4 in cervical squamous cell carcinoma (CSCC). One hundred and ninety-eight CSCC cases, 109 low-grade squamous intraepithelial lesions (LSILs), 141 high-grade squamous intraepithelial lesions (HSILs) and 63 chronic cervicitis were collected. The expression of RIPK4 was detected by immunohistochemistry (IHC), and its clinical value and oncogenic functions were further assessed. RIPK4 expression increased significantly with disease progression from 3.2% in chronic cervicitis, 19.3% in LSILs and 85.1% in HSILs to 94.4% in CSCCs (P < 0.001). Moreover, RIPK4 may serve as a useful biomarker to distinguish HSIL from chronic cervicitis/LSIL, which are two different clinical types for therapeutic procedures, with a high sensitivity and specificity (85.1% and 86.6%, respectively) and the performance improved when combined with p16(INK4a). Further, RIPK4 overexpression was associated with overall (HR = 2.085, P = 0.038) and disease-free survival (HR = 1.742, P = 0.037). Knockdown of RIPK4 reduced cell migration and invasion via inhibition of Vimentin, MMP2 and Fibronectin expression in cervical cancer cells. RIPK4 might act as a potential diagnostic and independent prognostic biomarker for CSCC patients.
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spelling pubmed-44937022015-07-09 Increased RIPK4 expression is associated with progression and poor prognosis in cervical squamous cell carcinoma patients Liu, De-Qing Li, Fang-Fang Zhang, Jiang-Bo Zhou, Tie-Jun Xue, Wen-Qiong Zheng, Xiao-Hui Chen, Yuan-Bin Liao, Xiao-Yu Zhang, Lan Zhang, Shao-Dan Hu, Ye-Zhu Jia, Wei-Hua Sci Rep Article Aberrant expression of receptor interacting protein kinase 4 (RIPK4), a crucial regulatory protein of Wnt/β-catenin signaling, has recently been reported to be involved in several cancers. Here, we report the potential clinical implication and biological functions of RIPK4 in cervical squamous cell carcinoma (CSCC). One hundred and ninety-eight CSCC cases, 109 low-grade squamous intraepithelial lesions (LSILs), 141 high-grade squamous intraepithelial lesions (HSILs) and 63 chronic cervicitis were collected. The expression of RIPK4 was detected by immunohistochemistry (IHC), and its clinical value and oncogenic functions were further assessed. RIPK4 expression increased significantly with disease progression from 3.2% in chronic cervicitis, 19.3% in LSILs and 85.1% in HSILs to 94.4% in CSCCs (P < 0.001). Moreover, RIPK4 may serve as a useful biomarker to distinguish HSIL from chronic cervicitis/LSIL, which are two different clinical types for therapeutic procedures, with a high sensitivity and specificity (85.1% and 86.6%, respectively) and the performance improved when combined with p16(INK4a). Further, RIPK4 overexpression was associated with overall (HR = 2.085, P = 0.038) and disease-free survival (HR = 1.742, P = 0.037). Knockdown of RIPK4 reduced cell migration and invasion via inhibition of Vimentin, MMP2 and Fibronectin expression in cervical cancer cells. RIPK4 might act as a potential diagnostic and independent prognostic biomarker for CSCC patients. Nature Publishing Group 2015-07-07 /pmc/articles/PMC4493702/ /pubmed/26148476 http://dx.doi.org/10.1038/srep11955 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Liu, De-Qing
Li, Fang-Fang
Zhang, Jiang-Bo
Zhou, Tie-Jun
Xue, Wen-Qiong
Zheng, Xiao-Hui
Chen, Yuan-Bin
Liao, Xiao-Yu
Zhang, Lan
Zhang, Shao-Dan
Hu, Ye-Zhu
Jia, Wei-Hua
Increased RIPK4 expression is associated with progression and poor prognosis in cervical squamous cell carcinoma patients
title Increased RIPK4 expression is associated with progression and poor prognosis in cervical squamous cell carcinoma patients
title_full Increased RIPK4 expression is associated with progression and poor prognosis in cervical squamous cell carcinoma patients
title_fullStr Increased RIPK4 expression is associated with progression and poor prognosis in cervical squamous cell carcinoma patients
title_full_unstemmed Increased RIPK4 expression is associated with progression and poor prognosis in cervical squamous cell carcinoma patients
title_short Increased RIPK4 expression is associated with progression and poor prognosis in cervical squamous cell carcinoma patients
title_sort increased ripk4 expression is associated with progression and poor prognosis in cervical squamous cell carcinoma patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493702/
https://www.ncbi.nlm.nih.gov/pubmed/26148476
http://dx.doi.org/10.1038/srep11955
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