Interactome analysis brings splicing into focus

The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing. Please see related Researc...

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Detalles Bibliográficos
Autores principales: Dominguez, Daniel, Burge, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493805/
https://www.ncbi.nlm.nih.gov/pubmed/26149273
http://dx.doi.org/10.1186/s13059-015-0707-0
Descripción
Sumario:The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing. Please see related Research article: http://www.genomebiology.com/2015/16/1/119/abstract

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