Interactome analysis brings splicing into focus

The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing. Please see related Researc...

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Detalles Bibliográficos
Autores principales: Dominguez, Daniel, Burge, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493805/
https://www.ncbi.nlm.nih.gov/pubmed/26149273
http://dx.doi.org/10.1186/s13059-015-0707-0
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author Dominguez, Daniel
Burge, Christopher B.
author_facet Dominguez, Daniel
Burge, Christopher B.
author_sort Dominguez, Daniel
collection PubMed
description The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing. Please see related Research article: http://www.genomebiology.com/2015/16/1/119/abstract
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spelling pubmed-44938052015-07-08 Interactome analysis brings splicing into focus Dominguez, Daniel Burge, Christopher B. Genome Biol Research Highlight The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing. Please see related Research article: http://www.genomebiology.com/2015/16/1/119/abstract BioMed Central 2015-07-07 2015 /pmc/articles/PMC4493805/ /pubmed/26149273 http://dx.doi.org/10.1186/s13059-015-0707-0 Text en © Dominguez and Burge. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Dominguez, Daniel
Burge, Christopher B.
Interactome analysis brings splicing into focus
title Interactome analysis brings splicing into focus
title_full Interactome analysis brings splicing into focus
title_fullStr Interactome analysis brings splicing into focus
title_full_unstemmed Interactome analysis brings splicing into focus
title_short Interactome analysis brings splicing into focus
title_sort interactome analysis brings splicing into focus
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493805/
https://www.ncbi.nlm.nih.gov/pubmed/26149273
http://dx.doi.org/10.1186/s13059-015-0707-0
work_keys_str_mv AT dominguezdaniel interactomeanalysisbringssplicingintofocus
AT burgechristopherb interactomeanalysisbringssplicingintofocus

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