p53 protects against genome instability following centriole duplication failure

Centriole function has been difficult to study because of a lack of specific tools that allow persistent and reversible centriole depletion. Here we combined gene targeting with an auxin-inducible degradation system to achieve rapid, titratable, and reversible control of Polo-like kinase 4 (Plk4), a...

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Detalles Bibliográficos
Autores principales: Lambrus, Bramwell G., Uetake, Yumi, Clutario, Kevin M., Daggubati, Vikas, Snyder, Michael, Sluder, Greenfield, Holland, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494000/
https://www.ncbi.nlm.nih.gov/pubmed/26150389
http://dx.doi.org/10.1083/jcb.201502089

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