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Emerging treatments and combinations in the management of NSCLC: clinical potential of nintedanib

There remains an unmet need for effective, well-tolerated treatment options in advanced non-small cell lung cancer (NSCLC) to alleviate the disease burden for a broad selection of patients. Nintedanib is a potent, oral, triple angiokinase inhibitor of vascular endothelial growth factor, fibroblast g...

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Autores principales: Reck, Martin, Mellemgaard, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494183/
https://www.ncbi.nlm.nih.gov/pubmed/26170616
http://dx.doi.org/10.2147/BTT.S57356
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author Reck, Martin
Mellemgaard, Anders
author_facet Reck, Martin
Mellemgaard, Anders
author_sort Reck, Martin
collection PubMed
description There remains an unmet need for effective, well-tolerated treatment options in advanced non-small cell lung cancer (NSCLC) to alleviate the disease burden for a broad selection of patients. Nintedanib is a potent, oral, triple angiokinase inhibitor of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor, and was recently approved in Europe for use in combination with docetaxel for the treatment of adults with locally advanced, metastatic, or locally recurrent NSCLC of adenocarcinoma tumor histology, following first-line chemotherapy. Nintedanib has been investigated extensively in preclinical research and in a number of clinical studies, the most important of which was the Phase III LUME-Lung 1 study, which investigated nintedanib in combination with docetaxel in patients with advanced NSCLC after failure of first-line chemotherapy. In this study, which led to the approval of nintedanib, addition of nintedanib to docetaxel significantly improved overall survival in patients with adenocarcinoma histology. Nintedanib demonstrated a manageable safety profile in combination with docetaxel. This review focuses on the clinical experience with nintedanib in NSCLC and discusses the clinical potential of this agent for use in combination with chemotherapy.
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spelling pubmed-44941832015-07-13 Emerging treatments and combinations in the management of NSCLC: clinical potential of nintedanib Reck, Martin Mellemgaard, Anders Biologics Review There remains an unmet need for effective, well-tolerated treatment options in advanced non-small cell lung cancer (NSCLC) to alleviate the disease burden for a broad selection of patients. Nintedanib is a potent, oral, triple angiokinase inhibitor of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor, and was recently approved in Europe for use in combination with docetaxel for the treatment of adults with locally advanced, metastatic, or locally recurrent NSCLC of adenocarcinoma tumor histology, following first-line chemotherapy. Nintedanib has been investigated extensively in preclinical research and in a number of clinical studies, the most important of which was the Phase III LUME-Lung 1 study, which investigated nintedanib in combination with docetaxel in patients with advanced NSCLC after failure of first-line chemotherapy. In this study, which led to the approval of nintedanib, addition of nintedanib to docetaxel significantly improved overall survival in patients with adenocarcinoma histology. Nintedanib demonstrated a manageable safety profile in combination with docetaxel. This review focuses on the clinical experience with nintedanib in NSCLC and discusses the clinical potential of this agent for use in combination with chemotherapy. Dove Medical Press 2015-07-01 /pmc/articles/PMC4494183/ /pubmed/26170616 http://dx.doi.org/10.2147/BTT.S57356 Text en © 2015 Reck and Mellemgaard. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Reck, Martin
Mellemgaard, Anders
Emerging treatments and combinations in the management of NSCLC: clinical potential of nintedanib
title Emerging treatments and combinations in the management of NSCLC: clinical potential of nintedanib
title_full Emerging treatments and combinations in the management of NSCLC: clinical potential of nintedanib
title_fullStr Emerging treatments and combinations in the management of NSCLC: clinical potential of nintedanib
title_full_unstemmed Emerging treatments and combinations in the management of NSCLC: clinical potential of nintedanib
title_short Emerging treatments and combinations in the management of NSCLC: clinical potential of nintedanib
title_sort emerging treatments and combinations in the management of nsclc: clinical potential of nintedanib
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494183/
https://www.ncbi.nlm.nih.gov/pubmed/26170616
http://dx.doi.org/10.2147/BTT.S57356
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