Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens

The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed...

Descripción completa

Detalles Bibliográficos
Autor principal: Sattentau, Quentin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494206/
https://www.ncbi.nlm.nih.gov/pubmed/26344344
http://dx.doi.org/10.3390/vaccines1040497
_version_ 1782380043754799104
author Sattentau, Quentin J.
author_facet Sattentau, Quentin J.
author_sort Sattentau, Quentin J.
collection PubMed
description The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome.
format Online
Article
Text
id pubmed-4494206
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-44942062015-08-31 Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens Sattentau, Quentin J. Vaccines (Basel) Review The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome. MDPI 2013-10-28 /pmc/articles/PMC4494206/ /pubmed/26344344 http://dx.doi.org/10.3390/vaccines1040497 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Sattentau, Quentin J.
Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
title Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
title_full Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
title_fullStr Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
title_full_unstemmed Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
title_short Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
title_sort envelope glycoprotein trimers as hiv-1 vaccine immunogens
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494206/
https://www.ncbi.nlm.nih.gov/pubmed/26344344
http://dx.doi.org/10.3390/vaccines1040497
work_keys_str_mv AT sattentauquentinj envelopeglycoproteintrimersashiv1vaccineimmunogens

Ejemplares similares