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Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification
Synthetic tumor vaccines have been proven to be promising for cancer immunotherapy. However, the limitation of the specificity and efficiency of the synthetic tumor vaccines need further improvements. To overcome these difficulties, additional tumor-associated targets need to be identified, and opti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494217/ https://www.ncbi.nlm.nih.gov/pubmed/26344745 http://dx.doi.org/10.3390/vaccines2030549 |
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author | Huang, Zhi-Hua Sun, Zhan-Yi Gao, Yue Chen, Pu-Guang Liu, Yan-Fang Chen, Yong-Xiang Li, Yan-Mei |
author_facet | Huang, Zhi-Hua Sun, Zhan-Yi Gao, Yue Chen, Pu-Guang Liu, Yan-Fang Chen, Yong-Xiang Li, Yan-Mei |
author_sort | Huang, Zhi-Hua |
collection | PubMed |
description | Synthetic tumor vaccines have been proven to be promising for cancer immunotherapy. However, the limitation of the specificity and efficiency of the synthetic tumor vaccines need further improvements. To overcome these difficulties, additional tumor-associated targets need to be identified, and optimized structural designs of vaccines need to be elaborated. In this review, we summarized the main strategies pursued in the design of synthetic tumor vaccines, such as multi-component, multivalency, antigen modification and other possible ways to improve the efficiency of synthetic tumor vaccines. |
format | Online Article Text |
id | pubmed-4494217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44942172015-08-31 Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification Huang, Zhi-Hua Sun, Zhan-Yi Gao, Yue Chen, Pu-Guang Liu, Yan-Fang Chen, Yong-Xiang Li, Yan-Mei Vaccines (Basel) Review Synthetic tumor vaccines have been proven to be promising for cancer immunotherapy. However, the limitation of the specificity and efficiency of the synthetic tumor vaccines need further improvements. To overcome these difficulties, additional tumor-associated targets need to be identified, and optimized structural designs of vaccines need to be elaborated. In this review, we summarized the main strategies pursued in the design of synthetic tumor vaccines, such as multi-component, multivalency, antigen modification and other possible ways to improve the efficiency of synthetic tumor vaccines. MDPI 2014-07-15 /pmc/articles/PMC4494217/ /pubmed/26344745 http://dx.doi.org/10.3390/vaccines2030549 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Huang, Zhi-Hua Sun, Zhan-Yi Gao, Yue Chen, Pu-Guang Liu, Yan-Fang Chen, Yong-Xiang Li, Yan-Mei Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification |
title | Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification |
title_full | Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification |
title_fullStr | Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification |
title_full_unstemmed | Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification |
title_short | Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification |
title_sort | strategy for designing a synthetic tumor vaccine: multi-component, multivalency and antigen modification |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494217/ https://www.ncbi.nlm.nih.gov/pubmed/26344745 http://dx.doi.org/10.3390/vaccines2030549 |
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