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DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses

Plants represent a safe, efficacious and inexpensive production platform by which to provide vaccines and other therapeutic proteins to the world’s poor. Plant virus expression vector technology has rapidly become one of the most popular methods to express pharmaceutical proteins in plants. This rev...

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Detalles Bibliográficos
Autor principal: Hefferon, Kathleen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494219/
https://www.ncbi.nlm.nih.gov/pubmed/26344750
http://dx.doi.org/10.3390/vaccines2030642
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author Hefferon, Kathleen L.
author_facet Hefferon, Kathleen L.
author_sort Hefferon, Kathleen L.
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description Plants represent a safe, efficacious and inexpensive production platform by which to provide vaccines and other therapeutic proteins to the world’s poor. Plant virus expression vector technology has rapidly become one of the most popular methods to express pharmaceutical proteins in plants. This review discusses several of the state-of-the-art plant expression systems based upon geminiviruses that have been engineered for vaccine production. An overview of the advantages of these small, single-stranded DNA viruses is provided and comparisons are made with other virus expression systems. Advances in the design of several different geminivirus vectors are presented in this review, and examples of vaccines and other biologics generated from each are described.
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spelling pubmed-44942192015-08-31 DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses Hefferon, Kathleen L. Vaccines (Basel) Review Plants represent a safe, efficacious and inexpensive production platform by which to provide vaccines and other therapeutic proteins to the world’s poor. Plant virus expression vector technology has rapidly become one of the most popular methods to express pharmaceutical proteins in plants. This review discusses several of the state-of-the-art plant expression systems based upon geminiviruses that have been engineered for vaccine production. An overview of the advantages of these small, single-stranded DNA viruses is provided and comparisons are made with other virus expression systems. Advances in the design of several different geminivirus vectors are presented in this review, and examples of vaccines and other biologics generated from each are described. MDPI 2014-08-05 /pmc/articles/PMC4494219/ /pubmed/26344750 http://dx.doi.org/10.3390/vaccines2030642 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Hefferon, Kathleen L.
DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses
title DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses
title_full DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses
title_fullStr DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses
title_full_unstemmed DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses
title_short DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses
title_sort dna virus vectors for vaccine production in plants: spotlight on geminiviruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494219/
https://www.ncbi.nlm.nih.gov/pubmed/26344750
http://dx.doi.org/10.3390/vaccines2030642
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