HIV DNA Vaccine: Stepwise Improvements Make a Difference

Inefficient DNA delivery methods and low expression of plasmid DNA have been major obstacles for the use of plasmid DNA as vaccine for HIV/AIDS. This review describes successful efforts to improve DNA vaccine methodology over the past ~30 years. DNA vaccination, either alone or in combination with o...

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Autores principales: Felber, Barbara K., Valentin, Antonio, Rosati, Margherita, Bergamaschi, Cristina, Pavlakis, George N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494255/
https://www.ncbi.nlm.nih.gov/pubmed/26344623
http://dx.doi.org/10.3390/vaccines2020354
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author Felber, Barbara K.
Valentin, Antonio
Rosati, Margherita
Bergamaschi, Cristina
Pavlakis, George N.
author_facet Felber, Barbara K.
Valentin, Antonio
Rosati, Margherita
Bergamaschi, Cristina
Pavlakis, George N.
author_sort Felber, Barbara K.
collection PubMed
description Inefficient DNA delivery methods and low expression of plasmid DNA have been major obstacles for the use of plasmid DNA as vaccine for HIV/AIDS. This review describes successful efforts to improve DNA vaccine methodology over the past ~30 years. DNA vaccination, either alone or in combination with other methods, has the potential to be a rapid, safe, and effective vaccine platform against AIDS. Recent clinical trials suggest the feasibility of its translation to the clinic.
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spelling pubmed-44942552015-08-31 HIV DNA Vaccine: Stepwise Improvements Make a Difference Felber, Barbara K. Valentin, Antonio Rosati, Margherita Bergamaschi, Cristina Pavlakis, George N. Vaccines (Basel) Review Inefficient DNA delivery methods and low expression of plasmid DNA have been major obstacles for the use of plasmid DNA as vaccine for HIV/AIDS. This review describes successful efforts to improve DNA vaccine methodology over the past ~30 years. DNA vaccination, either alone or in combination with other methods, has the potential to be a rapid, safe, and effective vaccine platform against AIDS. Recent clinical trials suggest the feasibility of its translation to the clinic. MDPI 2014-05-14 /pmc/articles/PMC4494255/ /pubmed/26344623 http://dx.doi.org/10.3390/vaccines2020354 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Felber, Barbara K.
Valentin, Antonio
Rosati, Margherita
Bergamaschi, Cristina
Pavlakis, George N.
HIV DNA Vaccine: Stepwise Improvements Make a Difference
title HIV DNA Vaccine: Stepwise Improvements Make a Difference
title_full HIV DNA Vaccine: Stepwise Improvements Make a Difference
title_fullStr HIV DNA Vaccine: Stepwise Improvements Make a Difference
title_full_unstemmed HIV DNA Vaccine: Stepwise Improvements Make a Difference
title_short HIV DNA Vaccine: Stepwise Improvements Make a Difference
title_sort hiv dna vaccine: stepwise improvements make a difference
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494255/
https://www.ncbi.nlm.nih.gov/pubmed/26344623
http://dx.doi.org/10.3390/vaccines2020354
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