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Oncologic aspects of long-term followed incidental prostate cancer detected by cystoprostatectomy in Korean patients

PURPOSE: To determine the incidence and clinical features of incidentally discovered prostate adenocarcinoma in patients undergoing radical cystoprostatectomy (CPT) for bladder cancer. METHODS: Ninety-six consecutive patients scheduled to undergo CPT were prospectively enrolled. The prostates were e...

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Autores principales: Cho, In-Chang, Kim, Jeong Eun, Kim, Sung Han, Joung, Jae Young, Seo, Ho Kyung, Chung, Jinsoo, Park, Weon Seo, Lee, Kang Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian Pacific Prostate Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494634/
https://www.ncbi.nlm.nih.gov/pubmed/26157769
http://dx.doi.org/10.1016/j.prnil.2015.03.006
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author Cho, In-Chang
Kim, Jeong Eun
Kim, Sung Han
Joung, Jae Young
Seo, Ho Kyung
Chung, Jinsoo
Park, Weon Seo
Lee, Kang Hyun
author_facet Cho, In-Chang
Kim, Jeong Eun
Kim, Sung Han
Joung, Jae Young
Seo, Ho Kyung
Chung, Jinsoo
Park, Weon Seo
Lee, Kang Hyun
author_sort Cho, In-Chang
collection PubMed
description PURPOSE: To determine the incidence and clinical features of incidentally discovered prostate adenocarcinoma in patients undergoing radical cystoprostatectomy (CPT) for bladder cancer. METHODS: Ninety-six consecutive patients scheduled to undergo CPT were prospectively enrolled. The prostates were excised completely during CPT. The CPT specimens were examined, and the clinicopathologic characteristics of incidental prostate cancer studied. Complete transverse sections of the prostate were taken from the apex to the base at 4-mm intervals and all prostates were examined by a single pathologist. RESULTS: The mean patient age and prostate-specific antigen level were 66.1 ± 10.0 years and 2.8 ± 5.0 ng/mL, respectively. Of the 96 patients, 35 (36.5%) had prostate cancer (PCa). Of these incidental PCas, 57.1% (20.8% of all patients undergoing CPT) were clinically significant. None of the patients who were age ≤50 years had incidental PCa. However, the incidences of PCa in the 51–60 years, 61–70 years, and ≥71 years age groups were 27.8% (5/18), 48.7% (19/39), and 35.5% (15/31), respectively, and the difference according to the age subgroup was significant (P = 0.048). During the median follow-up of 49 months, 29.2% (28/96) of patients died. There were no PCa-specific deaths, and two patients (2.1%) showed biochemical recurrences. CONCLUSION: Incidental PCas were diagnosed in ∼40% of CPT specimens, and ∼50% of incidental PCas were clinically significant. During radical CPT in patients aged ≥60 years, the possibility of the presence of PCa and the potential oncologic risk of partial prostatectomy during CPT should be remembered.
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spelling pubmed-44946342015-07-08 Oncologic aspects of long-term followed incidental prostate cancer detected by cystoprostatectomy in Korean patients Cho, In-Chang Kim, Jeong Eun Kim, Sung Han Joung, Jae Young Seo, Ho Kyung Chung, Jinsoo Park, Weon Seo Lee, Kang Hyun Prostate Int Original Article PURPOSE: To determine the incidence and clinical features of incidentally discovered prostate adenocarcinoma in patients undergoing radical cystoprostatectomy (CPT) for bladder cancer. METHODS: Ninety-six consecutive patients scheduled to undergo CPT were prospectively enrolled. The prostates were excised completely during CPT. The CPT specimens were examined, and the clinicopathologic characteristics of incidental prostate cancer studied. Complete transverse sections of the prostate were taken from the apex to the base at 4-mm intervals and all prostates were examined by a single pathologist. RESULTS: The mean patient age and prostate-specific antigen level were 66.1 ± 10.0 years and 2.8 ± 5.0 ng/mL, respectively. Of the 96 patients, 35 (36.5%) had prostate cancer (PCa). Of these incidental PCas, 57.1% (20.8% of all patients undergoing CPT) were clinically significant. None of the patients who were age ≤50 years had incidental PCa. However, the incidences of PCa in the 51–60 years, 61–70 years, and ≥71 years age groups were 27.8% (5/18), 48.7% (19/39), and 35.5% (15/31), respectively, and the difference according to the age subgroup was significant (P = 0.048). During the median follow-up of 49 months, 29.2% (28/96) of patients died. There were no PCa-specific deaths, and two patients (2.1%) showed biochemical recurrences. CONCLUSION: Incidental PCas were diagnosed in ∼40% of CPT specimens, and ∼50% of incidental PCas were clinically significant. During radical CPT in patients aged ≥60 years, the possibility of the presence of PCa and the potential oncologic risk of partial prostatectomy during CPT should be remembered. Asian Pacific Prostate Society 2015-06 2015-04-07 /pmc/articles/PMC4494634/ /pubmed/26157769 http://dx.doi.org/10.1016/j.prnil.2015.03.006 Text en © 2015 Published by Elsevier B.V. on behalf of Prostate International. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Cho, In-Chang
Kim, Jeong Eun
Kim, Sung Han
Joung, Jae Young
Seo, Ho Kyung
Chung, Jinsoo
Park, Weon Seo
Lee, Kang Hyun
Oncologic aspects of long-term followed incidental prostate cancer detected by cystoprostatectomy in Korean patients
title Oncologic aspects of long-term followed incidental prostate cancer detected by cystoprostatectomy in Korean patients
title_full Oncologic aspects of long-term followed incidental prostate cancer detected by cystoprostatectomy in Korean patients
title_fullStr Oncologic aspects of long-term followed incidental prostate cancer detected by cystoprostatectomy in Korean patients
title_full_unstemmed Oncologic aspects of long-term followed incidental prostate cancer detected by cystoprostatectomy in Korean patients
title_short Oncologic aspects of long-term followed incidental prostate cancer detected by cystoprostatectomy in Korean patients
title_sort oncologic aspects of long-term followed incidental prostate cancer detected by cystoprostatectomy in korean patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494634/
https://www.ncbi.nlm.nih.gov/pubmed/26157769
http://dx.doi.org/10.1016/j.prnil.2015.03.006
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