Ikaros mutation confers integrin-dependent pre-B cell survival and progression to acute lymphoblastic leukemia

Deletion of the Ikaros (Ikzf1) DNA-binding domain generates dominant-negative isoforms that interfere with Ikaros family activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemias (B-ALL). Here, we show that conditional inactivation of the Ikaros DNA binding d...

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Detalles Bibliográficos
Autores principales: Joshi, Ila, Yoshida, Toshimi, Jena, Nilamani, Qi, Xiaoqing, Zhang, Jiangwen, Van Etten, Richard A., Georgopoulos, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494688/
https://www.ncbi.nlm.nih.gov/pubmed/24509510
http://dx.doi.org/10.1038/ni.2821

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