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First selective direct mono-arylation of piperidines using ruthenium-catalyzed C–H activation

ABSTRACT: A Ru-catalyzed mono-arylation in α-position of saturated cyclic amines is reported employing a C–H activation protocol. Substitution of the pyridine directing group with a bulky group, e.g., trifluoromethyl in the 3-position, proved to be crucial to avoid bis-arylation. This highly selecti...

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Detalles Bibliográficos
Autores principales:	Schwarz, Maria C., Dastbaravardeh, Navid, Kirchner, Karl, Schnürch, Michael, Mihovilovic, Marko D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Vienna 2013
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494768/ https://www.ncbi.nlm.nih.gov/pubmed/26166880 http://dx.doi.org/10.1007/s00706-013-0947-1

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