Synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives

ABSTRACT: Two series of novel 4-chloro-2-(benzylthio)-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamides and their N-aroyl derivatives have been synthesized and evaluated for in vitro anticancer activity against the full NCI-60 cell line panel. Most of the compounds exhibited antiproliferative activity. Am...

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Detalles Bibliográficos
Autores principales: Brożewicz, Kamil, Sławiński, Jarosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494775/
https://www.ncbi.nlm.nih.gov/pubmed/26166867
http://dx.doi.org/10.1007/s00706-012-0732-6
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author Brożewicz, Kamil
Sławiński, Jarosław
author_facet Brożewicz, Kamil
Sławiński, Jarosław
author_sort Brożewicz, Kamil
collection PubMed
description ABSTRACT: Two series of novel 4-chloro-2-(benzylthio)-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamides and their N-aroyl derivatives have been synthesized and evaluated for in vitro anticancer activity against the full NCI-60 cell line panel. Most of the compounds exhibited antiproliferative activity. Among them a compound bearing an N-(thien-2-ylcarbonyl) moiety showed broad-spectrum activity with 50% growth inhibition (GI(50)) values in the range of 2.02–7.82 μM over 50 cell lines. GRAPHICAL ABSTRACT: [Image: see text].
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spelling pubmed-44947752015-07-09 Synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives Brożewicz, Kamil Sławiński, Jarosław Monatsh Chem Original Paper ABSTRACT: Two series of novel 4-chloro-2-(benzylthio)-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamides and their N-aroyl derivatives have been synthesized and evaluated for in vitro anticancer activity against the full NCI-60 cell line panel. Most of the compounds exhibited antiproliferative activity. Among them a compound bearing an N-(thien-2-ylcarbonyl) moiety showed broad-spectrum activity with 50% growth inhibition (GI(50)) values in the range of 2.02–7.82 μM over 50 cell lines. GRAPHICAL ABSTRACT: [Image: see text]. Springer Vienna 2012-03-02 2012 /pmc/articles/PMC4494775/ /pubmed/26166867 http://dx.doi.org/10.1007/s00706-012-0732-6 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Brożewicz, Kamil
Sławiński, Jarosław
Synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives
title Synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives
title_full Synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives
title_fullStr Synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives
title_full_unstemmed Synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives
title_short Synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives
title_sort synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494775/
https://www.ncbi.nlm.nih.gov/pubmed/26166867
http://dx.doi.org/10.1007/s00706-012-0732-6
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AT sławinskijarosław synthesisandinvitroactivityofnovel2benzylthio4chloro5134oxadiazol2ylbenzenesulfonamidederivatives

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