The emerging role of CaMKII in cancer

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine kinases best known for its critical role in learning and memory. Recent studies suggested that high levels of CaMKII also expressed in variety of malignant diseases. In this review, we focus on the structure a...

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Detalles Bibliográficos
Autores principales: Wang, Yan-yang, Zhao, Ren, Zhe, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494900/
https://www.ncbi.nlm.nih.gov/pubmed/25961153
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author Wang, Yan-yang
Zhao, Ren
Zhe, Hong
author_facet Wang, Yan-yang
Zhao, Ren
Zhe, Hong
author_sort Wang, Yan-yang
collection PubMed
description Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine kinases best known for its critical role in learning and memory. Recent studies suggested that high levels of CaMKII also expressed in variety of malignant diseases. In this review, we focus on the structure and biology properties of CaMKII, including the role of CaMKII in the regulation of cancer progression and therapy response. We also describe the role of CaMKII in the diagnosis of different kinds of cancer and recent progress in the development of CaMKII inhibitors. These data establishes CaMKII as a novel target whose modulation presents new opportunities for cancer diagnosis and treatment.
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spelling pubmed-44949002015-07-13 The emerging role of CaMKII in cancer Wang, Yan-yang Zhao, Ren Zhe, Hong Oncotarget Review Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine kinases best known for its critical role in learning and memory. Recent studies suggested that high levels of CaMKII also expressed in variety of malignant diseases. In this review, we focus on the structure and biology properties of CaMKII, including the role of CaMKII in the regulation of cancer progression and therapy response. We also describe the role of CaMKII in the diagnosis of different kinds of cancer and recent progress in the development of CaMKII inhibitors. These data establishes CaMKII as a novel target whose modulation presents new opportunities for cancer diagnosis and treatment. Impact Journals LLC 2015-04-29 /pmc/articles/PMC4494900/ /pubmed/25961153 Text en Copyright: © 2015 Wang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Wang, Yan-yang
Zhao, Ren
Zhe, Hong
The emerging role of CaMKII in cancer
title The emerging role of CaMKII in cancer
title_full The emerging role of CaMKII in cancer
title_fullStr The emerging role of CaMKII in cancer
title_full_unstemmed The emerging role of CaMKII in cancer
title_short The emerging role of CaMKII in cancer
title_sort emerging role of camkii in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494900/
https://www.ncbi.nlm.nih.gov/pubmed/25961153
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