Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition

We identified a synthetic lethality between PLK1 silencing and the expression of an oncogenic Epidermal Growth Factor Receptor, EGFRvIII. PLK1 promoted homologous recombination (HR), mitigating EGFRvIII induced oncogenic stress resulting from DNA damage accumulation. Accordingly, PLK1 inhibition enh...

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Detalles Bibliográficos
Autores principales: Shen, Ying, Li, Jie, Nitta, Masayuki, Futalan, Diahnn, Steed, Tyler, Treiber, Jeffrey M., Taich, Zack, Stevens, Deanna, Wykosky, Jill, Chen, Hong-Zhuan, Carter, Bob S., Becher, Oren J., Kennedy, Richard, Esashi, Fumiko, Sarkaria, Jann N., Furnari, Frank B., Cavenee, Webster K., Desai, Arshad, Chen, Clark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494902/
https://www.ncbi.nlm.nih.gov/pubmed/26059434

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