Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia

Despite the great success in using tyrosine kinase inhibitors (TKIs) to treat chronic myeloid leukemia (CML), the frequent development of multi-drug resistance, particularly the T315I mutation of BCR-ABL, remains a challenging issue. Enhancement of protein phosphatase 2A (PP2A) activity by dissociat...

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Detalles Bibliográficos
Autores principales: Wang, Shuzhen, Xie, Weiquan, Wang, Duowei, Peng, Zhigang, Zheng, Yan, Liu, Nan, Dai, Wen, Wang, Yang, Wang, Zongqiang, Yang, Yong, Chen, Yijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494927/
https://www.ncbi.nlm.nih.gov/pubmed/25900240

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