Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth

Ubiquitin E3 ligase MARCH7 is involved in T cell proliferation and neuronal development. We found that expression of MARCH7 was higher in ovarian cancer tissues than normal ovarian tissues. Silencing MARCH7 decreased cell proliferation, migration, and invasion. Ectopic expression of MARCH7 increased...

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Detalles Bibliográficos
Autores principales: Hu, Jianguo, Meng, Ying, Yu, Tinghe, Hu, Lina, Mao, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494930/
https://www.ncbi.nlm.nih.gov/pubmed/25895127
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author Hu, Jianguo
Meng, Ying
Yu, Tinghe
Hu, Lina
Mao, Ming
author_facet Hu, Jianguo
Meng, Ying
Yu, Tinghe
Hu, Lina
Mao, Ming
author_sort Hu, Jianguo
collection PubMed
description Ubiquitin E3 ligase MARCH7 is involved in T cell proliferation and neuronal development. We found that expression of MARCH7 was higher in ovarian cancer tissues than normal ovarian tissues. Silencing MARCH7 decreased cell proliferation, migration, and invasion. Ectopic expression of MARCH7 increased cell proliferation, migration and invasion. Silencing MARCH7 prevented ovarian cancer growth in mice. Silencing MARCH7 inhibited NFkB and Wnt/β-catenin pathway. In agreement, ectopically expressed MARCH7 activated NFkB and Wnt/β-catenin pathways. Finally, MARCH7 was regulated by miR-101. Thus, MARCH7 is oncogenic and a potential target (oncotarget) for ovarian cancer therapy.
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spelling pubmed-44949302015-07-13 Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth Hu, Jianguo Meng, Ying Yu, Tinghe Hu, Lina Mao, Ming Oncotarget Research Paper Ubiquitin E3 ligase MARCH7 is involved in T cell proliferation and neuronal development. We found that expression of MARCH7 was higher in ovarian cancer tissues than normal ovarian tissues. Silencing MARCH7 decreased cell proliferation, migration, and invasion. Ectopic expression of MARCH7 increased cell proliferation, migration and invasion. Silencing MARCH7 prevented ovarian cancer growth in mice. Silencing MARCH7 inhibited NFkB and Wnt/β-catenin pathway. In agreement, ectopically expressed MARCH7 activated NFkB and Wnt/β-catenin pathways. Finally, MARCH7 was regulated by miR-101. Thus, MARCH7 is oncogenic and a potential target (oncotarget) for ovarian cancer therapy. Impact Journals LLC 2015-03-26 /pmc/articles/PMC4494930/ /pubmed/25895127 Text en Copyright: © 2015 Hu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Hu, Jianguo
Meng, Ying
Yu, Tinghe
Hu, Lina
Mao, Ming
Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth
title Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth
title_full Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth
title_fullStr Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth
title_full_unstemmed Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth
title_short Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth
title_sort ubiquitin e3 ligase march7 promotes ovarian tumor growth
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494930/
https://www.ncbi.nlm.nih.gov/pubmed/25895127
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AT mengying ubiquitine3ligasemarch7promotesovariantumorgrowth
AT yutinghe ubiquitine3ligasemarch7promotesovariantumorgrowth
AT hulina ubiquitine3ligasemarch7promotesovariantumorgrowth
AT maoming ubiquitine3ligasemarch7promotesovariantumorgrowth

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