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5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair

Malignant tumors of the rectum are treated by neoadjuvant radiochemotherapy. This involves a combination of 5-fluorouracil (5-FU) and double stranded DNA-break (DSB)-inducing radiotherapy. Here we explored how 5-FU cooperates with DSB-induction to achieve sustainable DNA damage in colorectal cancer...

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Detalles Bibliográficos
Autores principales:	Srinivas, Upadhyayula Sai, Dyczkowski, Jerzy, Beißbarth, Tim, Gaedcke, Jochen, Mansour, Wael Y., Borgmann, Kerstin, Dobbelstein, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494959/ https://www.ncbi.nlm.nih.gov/pubmed/25909291

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