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Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

The anti-apoptotic BCL-2 family proteins are important targets for cancer chemotherapy. Specific and potent inhibitors of the BCL-2 family, such as ABT-263 (navitoclax) and ABT-199, are only effective against some members of the BCL-2 family but do not target MCL-1, which is commonly amplified in tu...

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Detalles Bibliográficos
Autores principales:	Varadarajan, Shankar, Poornima, Paramasivan, Milani, Mateus, Gowda, Krishne, Amin, Shantu, Wang, Hong-Gang, Cohen, Gerald M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494965/ https://www.ncbi.nlm.nih.gov/pubmed/26059440

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