Metformin potentiates rapamycin and cisplatin in gastric cancer in mice

Here we showed that pAMPKα and PTEN were down-regulated and p-mTOR, p-S6, p-4EBP1, MMP7, and DCN1 were up-regulated in human gastric cancer tissue samples as compared to that in the noncancerous tissues. Metformin inhibited tumor growth in mice. Also it enhanced cisplatin- or rapamycin-induced reduc...

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Detalles Bibliográficos
Autores principales: Yu, Yu, Fang, Wenzheng, Xia, Tian, Chen, Ying, Gao, Yunshu, Jiao, Xiaodong, Huang, Suyun, Wang, Jiejun, Li, Zhaosheng, Xie, Keping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494971/
https://www.ncbi.nlm.nih.gov/pubmed/25909163

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