Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions

ABSTRACT: An efficient method for the synthesis of N,N-bis(phenacyl)anilines was developed via smooth condensation of anilines with α-bromoacetophenones in the presence of sodium carbonate as acid acceptor and polyethylene glycol 400 (PEG 400) as catalyst at room temperature under solvent-free condi...

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Detalles Bibliográficos
Autores principales: He, Jingyu, Shi, Lanxiang, Liu, Sijie, Jia, Peng, Wang, Juan, Hu, Ruisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495021/
https://www.ncbi.nlm.nih.gov/pubmed/26166887
http://dx.doi.org/10.1007/s00706-013-0978-7
Descripción
Sumario:ABSTRACT: An efficient method for the synthesis of N,N-bis(phenacyl)anilines was developed via smooth condensation of anilines with α-bromoacetophenones in the presence of sodium carbonate as acid acceptor and polyethylene glycol 400 (PEG 400) as catalyst at room temperature under solvent-free conditions by using 350 W ultrasound irradiation. In addition to experimental simplicity, the main advantages of the procedure are mild conditions, short reaction times (30–45 min), and high yields (73–83 %). GRAPHICAL ABSTRACT: [Image: see text]

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