Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions

ABSTRACT: An efficient method for the synthesis of N,N-bis(phenacyl)anilines was developed via smooth condensation of anilines with α-bromoacetophenones in the presence of sodium carbonate as acid acceptor and polyethylene glycol 400 (PEG 400) as catalyst at room temperature under solvent-free condi...

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Detalles Bibliográficos
Autores principales: He, Jingyu, Shi, Lanxiang, Liu, Sijie, Jia, Peng, Wang, Juan, Hu, Ruisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495021/
https://www.ncbi.nlm.nih.gov/pubmed/26166887
http://dx.doi.org/10.1007/s00706-013-0978-7
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author He, Jingyu
Shi, Lanxiang
Liu, Sijie
Jia, Peng
Wang, Juan
Hu, Ruisheng
author_facet He, Jingyu
Shi, Lanxiang
Liu, Sijie
Jia, Peng
Wang, Juan
Hu, Ruisheng
author_sort He, Jingyu
collection PubMed
description ABSTRACT: An efficient method for the synthesis of N,N-bis(phenacyl)anilines was developed via smooth condensation of anilines with α-bromoacetophenones in the presence of sodium carbonate as acid acceptor and polyethylene glycol 400 (PEG 400) as catalyst at room temperature under solvent-free conditions by using 350 W ultrasound irradiation. In addition to experimental simplicity, the main advantages of the procedure are mild conditions, short reaction times (30–45 min), and high yields (73–83 %). GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-44950212015-07-09 Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions He, Jingyu Shi, Lanxiang Liu, Sijie Jia, Peng Wang, Juan Hu, Ruisheng Monatsh Chem Original Paper ABSTRACT: An efficient method for the synthesis of N,N-bis(phenacyl)anilines was developed via smooth condensation of anilines with α-bromoacetophenones in the presence of sodium carbonate as acid acceptor and polyethylene glycol 400 (PEG 400) as catalyst at room temperature under solvent-free conditions by using 350 W ultrasound irradiation. In addition to experimental simplicity, the main advantages of the procedure are mild conditions, short reaction times (30–45 min), and high yields (73–83 %). GRAPHICAL ABSTRACT: [Image: see text] Springer Vienna 2013-04-26 2014 /pmc/articles/PMC4495021/ /pubmed/26166887 http://dx.doi.org/10.1007/s00706-013-0978-7 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
He, Jingyu
Shi, Lanxiang
Liu, Sijie
Jia, Peng
Wang, Juan
Hu, Ruisheng
Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions
title Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions
title_full Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions
title_fullStr Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions
title_full_unstemmed Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions
title_short Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions
title_sort ultrasound-mediated synthesis of n,n-bis(phenacyl)aniline under solvent-free conditions
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495021/
https://www.ncbi.nlm.nih.gov/pubmed/26166887
http://dx.doi.org/10.1007/s00706-013-0978-7
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