Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions

ABSTRACT: A series of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles were efficiently synthesized by cyclocondensation of the appropriate 3-(pyridyl)acrylohydrazides with triethyl orthoesters in the presence of glacial acetic acid. The products were identified by means of spectroscopic...

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Autores principales: Kudelko, Agnieszka, Jasiak, Karolina, Ejsmont, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495023/
https://www.ncbi.nlm.nih.gov/pubmed/26166897
http://dx.doi.org/10.1007/s00706-014-1355-x
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author Kudelko, Agnieszka
Jasiak, Karolina
Ejsmont, Krzysztof
author_facet Kudelko, Agnieszka
Jasiak, Karolina
Ejsmont, Krzysztof
author_sort Kudelko, Agnieszka
collection PubMed
description ABSTRACT: A series of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles were efficiently synthesized by cyclocondensation of the appropriate 3-(pyridyl)acrylohydrazides with triethyl orthoesters in the presence of glacial acetic acid. The products were identified by means of spectroscopic methods and their pK (A) ionization constants were determined. The influence of substituents on the basicity of the pyridine system has been discussed. GRAPHICAL ABSTRACT: [Image: see text] [Image: see text]
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spelling pubmed-44950232015-07-09 Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions Kudelko, Agnieszka Jasiak, Karolina Ejsmont, Krzysztof Monatsh Chem Original Paper ABSTRACT: A series of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles were efficiently synthesized by cyclocondensation of the appropriate 3-(pyridyl)acrylohydrazides with triethyl orthoesters in the presence of glacial acetic acid. The products were identified by means of spectroscopic methods and their pK (A) ionization constants were determined. The influence of substituents on the basicity of the pyridine system has been discussed. GRAPHICAL ABSTRACT: [Image: see text] [Image: see text] Springer Vienna 2014-12-20 2015 /pmc/articles/PMC4495023/ /pubmed/26166897 http://dx.doi.org/10.1007/s00706-014-1355-x Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Kudelko, Agnieszka
Jasiak, Karolina
Ejsmont, Krzysztof
Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions
title Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions
title_full Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions
title_fullStr Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions
title_full_unstemmed Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions
title_short Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions
title_sort study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495023/
https://www.ncbi.nlm.nih.gov/pubmed/26166897
http://dx.doi.org/10.1007/s00706-014-1355-x
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