Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity

ABSTRACT: A series of novel 4-chloro-N-(4,5-dihydro-5-oxo-1-R(2)-1H-1,2,4-triazol-3-yl)-5-methyl-2-(R(1)-methylthio)benzenesulfonamide derivatives have been synthesized as potential anticancer agents. The in vitro antitumor activity of some compounds was evaluated in the US National Cancer Institute...

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Detalles Bibliográficos
Autores principales: Sławiński, Jarosław, Żołnowska, Beata, Orlewska, Czesława, Chojnacki, Jarosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495025/
https://www.ncbi.nlm.nih.gov/pubmed/26166861
http://dx.doi.org/10.1007/s00706-012-0849-7
Descripción
Sumario:ABSTRACT: A series of novel 4-chloro-N-(4,5-dihydro-5-oxo-1-R(2)-1H-1,2,4-triazol-3-yl)-5-methyl-2-(R(1)-methylthio)benzenesulfonamide derivatives have been synthesized as potential anticancer agents. The in vitro antitumor activity of some compounds was evaluated in the US National Cancer Institute (NCI) against the NCI-60 cell line panel. The most prominent compound showed remarkable activity against 13 human tumor cell lines representing lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast at low micromolar GI(50) level in the range of 1.9–3.0 μM. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00706-012-0849-7) contains supplementary material, which is available to authorized users.

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