Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity

ABSTRACT: A series of novel 4-chloro-N-(4,5-dihydro-5-oxo-1-R(2)-1H-1,2,4-triazol-3-yl)-5-methyl-2-(R(1)-methylthio)benzenesulfonamide derivatives have been synthesized as potential anticancer agents. The in vitro antitumor activity of some compounds was evaluated in the US National Cancer Institute...

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Detalles Bibliográficos
Autores principales: Sławiński, Jarosław, Żołnowska, Beata, Orlewska, Czesława, Chojnacki, Jarosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495025/
https://www.ncbi.nlm.nih.gov/pubmed/26166861
http://dx.doi.org/10.1007/s00706-012-0849-7
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author Sławiński, Jarosław
Żołnowska, Beata
Orlewska, Czesława
Chojnacki, Jarosław
author_facet Sławiński, Jarosław
Żołnowska, Beata
Orlewska, Czesława
Chojnacki, Jarosław
author_sort Sławiński, Jarosław
collection PubMed
description ABSTRACT: A series of novel 4-chloro-N-(4,5-dihydro-5-oxo-1-R(2)-1H-1,2,4-triazol-3-yl)-5-methyl-2-(R(1)-methylthio)benzenesulfonamide derivatives have been synthesized as potential anticancer agents. The in vitro antitumor activity of some compounds was evaluated in the US National Cancer Institute (NCI) against the NCI-60 cell line panel. The most prominent compound showed remarkable activity against 13 human tumor cell lines representing lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast at low micromolar GI(50) level in the range of 1.9–3.0 μM. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00706-012-0849-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-44950252015-07-09 Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity Sławiński, Jarosław Żołnowska, Beata Orlewska, Czesława Chojnacki, Jarosław Monatsh Chem Original Paper ABSTRACT: A series of novel 4-chloro-N-(4,5-dihydro-5-oxo-1-R(2)-1H-1,2,4-triazol-3-yl)-5-methyl-2-(R(1)-methylthio)benzenesulfonamide derivatives have been synthesized as potential anticancer agents. The in vitro antitumor activity of some compounds was evaluated in the US National Cancer Institute (NCI) against the NCI-60 cell line panel. The most prominent compound showed remarkable activity against 13 human tumor cell lines representing lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast at low micromolar GI(50) level in the range of 1.9–3.0 μM. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00706-012-0849-7) contains supplementary material, which is available to authorized users. Springer Vienna 2012-09-25 2012 /pmc/articles/PMC4495025/ /pubmed/26166861 http://dx.doi.org/10.1007/s00706-012-0849-7 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Sławiński, Jarosław
Żołnowska, Beata
Orlewska, Czesława
Chojnacki, Jarosław
Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity
title Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity
title_full Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity
title_fullStr Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity
title_full_unstemmed Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity
title_short Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity
title_sort synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-n-(4,5-dihydro-5-oxo-1h-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495025/
https://www.ncbi.nlm.nih.gov/pubmed/26166861
http://dx.doi.org/10.1007/s00706-012-0849-7
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