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Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells

Moderate DNA damage resulting from metabolic activities or sub-lethal doses of exogenous insults may eventually lead to cancer onset. Human 46BR.1G1 cells bear a mutation in replicative DNA ligase I (LigI) which results in low levels of replication-dependent DNA damage. This replication stress elici...

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Detalles Bibliográficos
Autores principales:	Cremaschi, Paolo, Oliverio, Matteo, Leva, Valentina, Bione, Silvia, Carriero, Roberta, Mazzucco, Giulia, Palamidessi, Andrea, Scita, Giorgio, Biamonti, Giuseppe, Montecucco, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495043/ https://www.ncbi.nlm.nih.gov/pubmed/26151554 http://dx.doi.org/10.1371/journal.pone.0130561

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