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Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State

Human embryonic stem cells (hESCs) undergo epigenetic changes in vitro which may compromise function, so an epigenetic pluripotency “signature” would be invaluable for line validation. We assessed Cytosine-phosphate-Guanine Island (CGI) methylation in hESCs by genomic DNA hybridisation to a CGI arra...

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Detalles Bibliográficos
Autores principales:	Pells, Steve, Koutsouraki, Eirini, Morfopoulou, Sofia, Valencia-Cadavid, Sara, Tomlinson, Simon R., Kalathur, Ravi, Futschik, Matthias E., De Sousa, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495055/ https://www.ncbi.nlm.nih.gov/pubmed/26151932 http://dx.doi.org/10.1371/journal.pone.0131102

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