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A comparison of different proportions of a ketamine-propofol mixture administered in a single injection for patients undergoing colonoscopy

INTRODUCTION: In this study, we aimed to determine the appropriate proportion of ketamine-propofol (ketofol), which was prepared in two different proportions for colonoscopy procedures. MATERIAL AND METHODS: This is a prospective and randomized trial. Group 1 was administered a mixture of 100 mg ket...

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Autores principales: Aydogmus, Meltem Türkay, Türk, Hacer Sebnem, Oba, Sibel, Gokalp, Oya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495153/
https://www.ncbi.nlm.nih.gov/pubmed/26170850
http://dx.doi.org/10.5114/aoms.2015.52360
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author Aydogmus, Meltem Türkay
Türk, Hacer Sebnem
Oba, Sibel
Gokalp, Oya
author_facet Aydogmus, Meltem Türkay
Türk, Hacer Sebnem
Oba, Sibel
Gokalp, Oya
author_sort Aydogmus, Meltem Türkay
collection PubMed
description INTRODUCTION: In this study, we aimed to determine the appropriate proportion of ketamine-propofol (ketofol), which was prepared in two different proportions for colonoscopy procedures. MATERIAL AND METHODS: This is a prospective and randomized trial. Group 1 was administered a mixture of 100 mg ketamine and 200 mg propofol. Group 2 was administered 50 mg ketamine and 200 mg propofol. Additional doses of 0.5 mg/kg bolus propofol without ketamine were administered to both groups to stabilize the bispectral index at 70–80 and with a Ramsey sedation score of 3–4. The pulse rate, mean arterial pressure (MAP), peripheral oxygen saturation values, colonoscopy period, adverse events, recovery time, discharge time, additional propofol doses, total propofol doses, colonoscopist and patient satisfaction were recorded. RESULTS: In group 2, the 1 min MAP mean was significantly lower than the initial, 10, 15 and 20 min MAP means (p = 0.014, p = 0.002). The 20 min PR mean of group 2 was statistically significantly higher than group 1 (p = 0.045). The 15 min PR mean of group 2 was significantly lower than the initial and the 1 min PR means (p = 0.023, p = 0.006). The total propofol dose mean of group 2 was significantly higher than group 1 (p = 0.0001). The presence of adverse events in group 2 was significantly lower than that in group 1 (p = 0.0001). The mean colonoscopist satisfaction in group 2 was significantly lower than that in group 1 (p = 0.047). CONCLUSIONS: In colonoscopy, a ketofol mixture prepared in the proportion 1 : 2 provides appropriate hemodynamic conditions and sufficient sedation.
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spelling pubmed-44951532015-07-13 A comparison of different proportions of a ketamine-propofol mixture administered in a single injection for patients undergoing colonoscopy Aydogmus, Meltem Türkay Türk, Hacer Sebnem Oba, Sibel Gokalp, Oya Arch Med Sci Clinical Research INTRODUCTION: In this study, we aimed to determine the appropriate proportion of ketamine-propofol (ketofol), which was prepared in two different proportions for colonoscopy procedures. MATERIAL AND METHODS: This is a prospective and randomized trial. Group 1 was administered a mixture of 100 mg ketamine and 200 mg propofol. Group 2 was administered 50 mg ketamine and 200 mg propofol. Additional doses of 0.5 mg/kg bolus propofol without ketamine were administered to both groups to stabilize the bispectral index at 70–80 and with a Ramsey sedation score of 3–4. The pulse rate, mean arterial pressure (MAP), peripheral oxygen saturation values, colonoscopy period, adverse events, recovery time, discharge time, additional propofol doses, total propofol doses, colonoscopist and patient satisfaction were recorded. RESULTS: In group 2, the 1 min MAP mean was significantly lower than the initial, 10, 15 and 20 min MAP means (p = 0.014, p = 0.002). The 20 min PR mean of group 2 was statistically significantly higher than group 1 (p = 0.045). The 15 min PR mean of group 2 was significantly lower than the initial and the 1 min PR means (p = 0.023, p = 0.006). The total propofol dose mean of group 2 was significantly higher than group 1 (p = 0.0001). The presence of adverse events in group 2 was significantly lower than that in group 1 (p = 0.0001). The mean colonoscopist satisfaction in group 2 was significantly lower than that in group 1 (p = 0.047). CONCLUSIONS: In colonoscopy, a ketofol mixture prepared in the proportion 1 : 2 provides appropriate hemodynamic conditions and sufficient sedation. Termedia Publishing House 2015-06-19 2015-06-19 /pmc/articles/PMC4495153/ /pubmed/26170850 http://dx.doi.org/10.5114/aoms.2015.52360 Text en Copyright © 2015 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Aydogmus, Meltem Türkay
Türk, Hacer Sebnem
Oba, Sibel
Gokalp, Oya
A comparison of different proportions of a ketamine-propofol mixture administered in a single injection for patients undergoing colonoscopy
title A comparison of different proportions of a ketamine-propofol mixture administered in a single injection for patients undergoing colonoscopy
title_full A comparison of different proportions of a ketamine-propofol mixture administered in a single injection for patients undergoing colonoscopy
title_fullStr A comparison of different proportions of a ketamine-propofol mixture administered in a single injection for patients undergoing colonoscopy
title_full_unstemmed A comparison of different proportions of a ketamine-propofol mixture administered in a single injection for patients undergoing colonoscopy
title_short A comparison of different proportions of a ketamine-propofol mixture administered in a single injection for patients undergoing colonoscopy
title_sort comparison of different proportions of a ketamine-propofol mixture administered in a single injection for patients undergoing colonoscopy
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495153/
https://www.ncbi.nlm.nih.gov/pubmed/26170850
http://dx.doi.org/10.5114/aoms.2015.52360
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