Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

The Hippo signaling pathway converges on YAP to regulate growth, differentiation, and regeneration. Previous studies with overexpressed proteins have shown that YAP is phosphorylated by its upstream kinase, Lats1/2, on multiple sites, including an evolutionarily conserved 14-3-3-binding site whose p...

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Detalles Bibliográficos
Autores principales: Chen, Qian, Zhang, Nailing, Xie, Rui, Wang, Wei, Cai, Jing, Choi, Kyung-Suk, David, Karen Kate, Huang, Bo, Yabuta, Norikazu, Nojima, Hiroshi, Anders, Robert A., Pan, Duojia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495399/
https://www.ncbi.nlm.nih.gov/pubmed/26109051
http://dx.doi.org/10.1101/gad.264234.115

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