Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells

Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be t...

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Autores principales: Huang, Aixue, Dong, Jie, Li, Shaohua, Wang, Chaonan, Ding, Hongmei, Li, Hui, Su, Xueting, Ge, Xingfeng, Sun, Leqiao, Bai, Chenjun, Shen, Xuelian, Fang, Tao, Li, Jie, Shao, Ningsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495413/
https://www.ncbi.nlm.nih.gov/pubmed/26157350
http://dx.doi.org/10.7150/ijbs.11943
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author Huang, Aixue
Dong, Jie
Li, Shaohua
Wang, Chaonan
Ding, Hongmei
Li, Hui
Su, Xueting
Ge, Xingfeng
Sun, Leqiao
Bai, Chenjun
Shen, Xuelian
Fang, Tao
Li, Jie
Shao, Ningsheng
author_facet Huang, Aixue
Dong, Jie
Li, Shaohua
Wang, Chaonan
Ding, Hongmei
Li, Hui
Su, Xueting
Ge, Xingfeng
Sun, Leqiao
Bai, Chenjun
Shen, Xuelian
Fang, Tao
Li, Jie
Shao, Ningsheng
author_sort Huang, Aixue
collection PubMed
description Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human umbilical vein endothelial cells (HUVECs) via receptor mediated endocytosis of exosomes, at least in part through HSPGs. The HepG2-derived VASN containing exosomes promote migration of recipient HUVECs cells. Our results identify a novel pathway by which a functional protein expressed in tumor cells affects the biological fate of endothelial cells via exosomes.
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spelling pubmed-44954132015-07-08 Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells Huang, Aixue Dong, Jie Li, Shaohua Wang, Chaonan Ding, Hongmei Li, Hui Su, Xueting Ge, Xingfeng Sun, Leqiao Bai, Chenjun Shen, Xuelian Fang, Tao Li, Jie Shao, Ningsheng Int J Biol Sci Research Paper Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human umbilical vein endothelial cells (HUVECs) via receptor mediated endocytosis of exosomes, at least in part through HSPGs. The HepG2-derived VASN containing exosomes promote migration of recipient HUVECs cells. Our results identify a novel pathway by which a functional protein expressed in tumor cells affects the biological fate of endothelial cells via exosomes. Ivyspring International Publisher 2015-06-11 /pmc/articles/PMC4495413/ /pubmed/26157350 http://dx.doi.org/10.7150/ijbs.11943 Text en © 2015 Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
spellingShingle Research Paper
Huang, Aixue
Dong, Jie
Li, Shaohua
Wang, Chaonan
Ding, Hongmei
Li, Hui
Su, Xueting
Ge, Xingfeng
Sun, Leqiao
Bai, Chenjun
Shen, Xuelian
Fang, Tao
Li, Jie
Shao, Ningsheng
Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells
title Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells
title_full Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells
title_fullStr Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells
title_full_unstemmed Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells
title_short Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells
title_sort exosomal transfer of vasorin expressed in hepatocellular carcinoma cells promotes migration of human umbilical vein endothelial cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495413/
https://www.ncbi.nlm.nih.gov/pubmed/26157350
http://dx.doi.org/10.7150/ijbs.11943
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