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Helicobacter pylori and gastric cancer: a state of the art review

Gastric cancer is the third most common cause of cancer-related death in the world. It is now well- established that Helicobacter pylori infection predispose individuals toward gastric adenocarcinoma later in life. It has since been classified as a class I carcinogen by the World Health Organization...

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Detalles Bibliográficos
Autores principales: Ishaq, Sauid, Nunn, Lois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495426/
https://www.ncbi.nlm.nih.gov/pubmed/26171139
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author Ishaq, Sauid
Nunn, Lois
author_facet Ishaq, Sauid
Nunn, Lois
author_sort Ishaq, Sauid
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description Gastric cancer is the third most common cause of cancer-related death in the world. It is now well- established that Helicobacter pylori infection predispose individuals toward gastric adenocarcinoma later in life. It has since been classified as a class I carcinogen by the World Health Organization. Research suggests that the oncogenic effects of Helicobacter pylori can occur through a variety of mechanisms, including the indirect inflammatory effects of Helicobacter pylori on the gastric mucosa and the direct epigenetic effects of Helicobacter pylori on individual cells. Whilst infected with Helicobacter pylori, a combination of environmental and host-dependent factors determines the likelihood of developing gastric cancer. Controversy remains regarding the effects of eradication of Helicobacter pylori on the prevention of further progression of gastric lesions and the possibility for regression of atrophic gastritis. The aim of this review is to synthesis different elements that contribute to the step-wise progression of normal gastric mucosa to gastric adenocarcinoma. This review helps clinicians to better identify those infected individuals who are at high risk of developing gastric cancer and implement the necessary investigations and treatment.
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spelling pubmed-44954262015-07-13 Helicobacter pylori and gastric cancer: a state of the art review Ishaq, Sauid Nunn, Lois Gastroenterol Hepatol Bed Bench Review Article Gastric cancer is the third most common cause of cancer-related death in the world. It is now well- established that Helicobacter pylori infection predispose individuals toward gastric adenocarcinoma later in life. It has since been classified as a class I carcinogen by the World Health Organization. Research suggests that the oncogenic effects of Helicobacter pylori can occur through a variety of mechanisms, including the indirect inflammatory effects of Helicobacter pylori on the gastric mucosa and the direct epigenetic effects of Helicobacter pylori on individual cells. Whilst infected with Helicobacter pylori, a combination of environmental and host-dependent factors determines the likelihood of developing gastric cancer. Controversy remains regarding the effects of eradication of Helicobacter pylori on the prevention of further progression of gastric lesions and the possibility for regression of atrophic gastritis. The aim of this review is to synthesis different elements that contribute to the step-wise progression of normal gastric mucosa to gastric adenocarcinoma. This review helps clinicians to better identify those infected individuals who are at high risk of developing gastric cancer and implement the necessary investigations and treatment. Shaheed Beheshti University of Medical Sciences 2015 /pmc/articles/PMC4495426/ /pubmed/26171139 Text en ©2015 RIGLD, Research Institute for Gastroenterology and Liver Diseases This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ishaq, Sauid
Nunn, Lois
Helicobacter pylori and gastric cancer: a state of the art review
title Helicobacter pylori and gastric cancer: a state of the art review
title_full Helicobacter pylori and gastric cancer: a state of the art review
title_fullStr Helicobacter pylori and gastric cancer: a state of the art review
title_full_unstemmed Helicobacter pylori and gastric cancer: a state of the art review
title_short Helicobacter pylori and gastric cancer: a state of the art review
title_sort helicobacter pylori and gastric cancer: a state of the art review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495426/
https://www.ncbi.nlm.nih.gov/pubmed/26171139
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