Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice

BACKGROUND: UBQLN2 mutations have recently been associated with familial forms of amyotrophic lateral sclerosis (ALS) and ALS-dementia. UBQLN2 encodes for ubiquilin-2, a member of the ubiquitin-like protein family which facilitates delivery of ubiquitinated proteins to the proteasome for degradation...

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Detalles Bibliográficos
Autores principales: Ceballos-Diaz, Carolina, Rosario, Awilda M., Park, Hyo-Jin, Chakrabarty, Paramita, Sacino, Amanda, Cruz, Pedro E., Siemienski, Zoe, Lara, Nicolas, Moran, Corey, Ravelo, Natalia, Golde, Todd E., McFarland, Nikolaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495639/
https://www.ncbi.nlm.nih.gov/pubmed/26152284
http://dx.doi.org/10.1186/s13024-015-0026-7

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