AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice

Recessive mutations in RLBP1 cause a form of retinitis pigmentosa in which the retina, before its degeneration leads to blindness, abnormally slowly recovers sensitivity after exposure to light. To develop a potential gene therapy for this condition, we tested multiple recombinant adeno-associated v...

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Detalles Bibliográficos
Autores principales: Choi, Vivian W, Bigelow, Chad E, McGee, Terri L, Gujar, Akshata N, Li, Hui, Hanks, Shawn M, Vrouvlianis, Joanna, Maker, Michael, Leehy, Barrett, Zhang, Yiqin, Aranda, Jorge, Bounoutas, George, Demirs, John T, Yang, Junzheng, Ornberg, Richard, Wang, Yu, Martin, Wendy, Stout, Kelly R, Argentieri, Gregory, Grosenstein, Paul, Diaz, Danielle, Turner, Oliver, Jaffee, Bruce D, Police, Seshidhar R, Dryja, Thaddeus P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495722/
https://www.ncbi.nlm.nih.gov/pubmed/26199951
http://dx.doi.org/10.1038/mtm.2015.22

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