Pharmacological Targeting of the Mammalian Clock Regulates Sleep Architecture and Emotional Behavior

Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here, we demonstrate that synthetic ligands targeting a key component of the mammalia...

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Detalles Bibliográficos
Autores principales: Banerjee, Subhashis, Wang, Yongjun, Solt, Laura A., Griffett, Kristine, Kazantzis, Melissa, Amador, Ariadna, El-Gendy, Bahaa M., Huitron-Resendiz, Salvador, Roberts, Amanda J., Shin, Youseung, Kamenecka, Theodore M., Burris, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495958/
https://www.ncbi.nlm.nih.gov/pubmed/25536025
http://dx.doi.org/10.1038/ncomms6759

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