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RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms’ Tumor in Chinese Children

BACKGROUND: Wilms’ tumor (WT) is the most common malignant renal tumor in children. Previous studies suggested the reversion-inducing, cysteine-rich protein with Kazal motifs (RECK) down-regulation might have a role in numerous human cancers. The current study was done to investigate the association...

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Autores principales: Yu, Yang, Hu, Yuanjun, Li, Kaisheng, Chen, Zhihong, Zhang, Hongmei, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496031/
https://www.ncbi.nlm.nih.gov/pubmed/26141647
http://dx.doi.org/10.12659/MSM.893606
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author Yu, Yang
Hu, Yuanjun
Li, Kaisheng
Chen, Zhihong
Zhang, Hongmei
Zhang, Lei
author_facet Yu, Yang
Hu, Yuanjun
Li, Kaisheng
Chen, Zhihong
Zhang, Hongmei
Zhang, Lei
author_sort Yu, Yang
collection PubMed
description BACKGROUND: Wilms’ tumor (WT) is the most common malignant renal tumor in children. Previous studies suggested the reversion-inducing, cysteine-rich protein with Kazal motifs (RECK) down-regulation might have a role in numerous human cancers. The current study was done to investigate the associations of RECK single-nucleotide polymorphisms (SNPs) with the WT susceptibility in Chinese children. MATERIAL/METHODS: We analyzed 2 SNPs (rs10972727and rs11788747) in a total of 97 WT children and 194 healthy matched controls (1:2 ratio) by real-time PCR and PCR-RFLP genotyping analysis. RESULTS: We found that the G allele of rs11788747 in the RECK gene was significantly associated with WT in Chinese children (OR=0.7, 95% CI: 0.45–0.99; P=0.042); as with another SNP rs10972727, however, no statistically significant difference was detected. Further analysis showed there was also a statistically significant difference in genotype frequencies between terminal tumor stage (P=0.026) and metastatic groups (P=0.002). CONCLUSIONS: The present data indicate that there is a significant association between mutant G of rs11788747 in RECK and WT risk. G carriers with advanced tumor stage or with metastasis might have an increased risk of WT.
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spelling pubmed-44960312015-07-16 RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms’ Tumor in Chinese Children Yu, Yang Hu, Yuanjun Li, Kaisheng Chen, Zhihong Zhang, Hongmei Zhang, Lei Med Sci Monit Clinical Research BACKGROUND: Wilms’ tumor (WT) is the most common malignant renal tumor in children. Previous studies suggested the reversion-inducing, cysteine-rich protein with Kazal motifs (RECK) down-regulation might have a role in numerous human cancers. The current study was done to investigate the associations of RECK single-nucleotide polymorphisms (SNPs) with the WT susceptibility in Chinese children. MATERIAL/METHODS: We analyzed 2 SNPs (rs10972727and rs11788747) in a total of 97 WT children and 194 healthy matched controls (1:2 ratio) by real-time PCR and PCR-RFLP genotyping analysis. RESULTS: We found that the G allele of rs11788747 in the RECK gene was significantly associated with WT in Chinese children (OR=0.7, 95% CI: 0.45–0.99; P=0.042); as with another SNP rs10972727, however, no statistically significant difference was detected. Further analysis showed there was also a statistically significant difference in genotype frequencies between terminal tumor stage (P=0.026) and metastatic groups (P=0.002). CONCLUSIONS: The present data indicate that there is a significant association between mutant G of rs11788747 in RECK and WT risk. G carriers with advanced tumor stage or with metastasis might have an increased risk of WT. International Scientific Literature, Inc. 2015-07-03 /pmc/articles/PMC4496031/ /pubmed/26141647 http://dx.doi.org/10.12659/MSM.893606 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Clinical Research
Yu, Yang
Hu, Yuanjun
Li, Kaisheng
Chen, Zhihong
Zhang, Hongmei
Zhang, Lei
RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms’ Tumor in Chinese Children
title RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms’ Tumor in Chinese Children
title_full RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms’ Tumor in Chinese Children
title_fullStr RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms’ Tumor in Chinese Children
title_full_unstemmed RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms’ Tumor in Chinese Children
title_short RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms’ Tumor in Chinese Children
title_sort reck gene polymorphism is associated with susceptibility and prognosis of wilms’ tumor in chinese children
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496031/
https://www.ncbi.nlm.nih.gov/pubmed/26141647
http://dx.doi.org/10.12659/MSM.893606
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