The rat as an animal model of Alzheimer’s disease

As a disease model, the laboratory rat has contributed enormously to neuroscience research over the years. It has also been a popular animal model for Alzheimer’s disease but its popularity has diminished during the last decade, as techniques for genetic manipulation in rats have lagged behind that...

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Detalles Bibliográficos
Autores principales: Benedikz, Eirikur, Kloskowska, Ewa, Winblad, Bengt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2009
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496102/
https://www.ncbi.nlm.nih.gov/pubmed/19432812
http://dx.doi.org/10.1111/j.1582-4934.2009.00781.x
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author Benedikz, Eirikur
Kloskowska, Ewa
Winblad, Bengt
author_facet Benedikz, Eirikur
Kloskowska, Ewa
Winblad, Bengt
author_sort Benedikz, Eirikur
collection PubMed
description As a disease model, the laboratory rat has contributed enormously to neuroscience research over the years. It has also been a popular animal model for Alzheimer’s disease but its popularity has diminished during the last decade, as techniques for genetic manipulation in rats have lagged behind that of mice. In recent years, the rat has been making a comeback as an Alzheimer’s disease model and the appearance of increasing numbers of transgenic rats will be a welcome and valuable complement to the existing mouse models. This review summarizes the contributions and current status of the rat as an animal model of Alzheimer’s disease.
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spelling pubmed-44961022015-07-13 The rat as an animal model of Alzheimer’s disease Benedikz, Eirikur Kloskowska, Ewa Winblad, Bengt J Cell Mol Med Reviews As a disease model, the laboratory rat has contributed enormously to neuroscience research over the years. It has also been a popular animal model for Alzheimer’s disease but its popularity has diminished during the last decade, as techniques for genetic manipulation in rats have lagged behind that of mice. In recent years, the rat has been making a comeback as an Alzheimer’s disease model and the appearance of increasing numbers of transgenic rats will be a welcome and valuable complement to the existing mouse models. This review summarizes the contributions and current status of the rat as an animal model of Alzheimer’s disease. John Wiley & Sons, Ltd 2009-06 2009-05-11 /pmc/articles/PMC4496102/ /pubmed/19432812 http://dx.doi.org/10.1111/j.1582-4934.2009.00781.x Text en © 2009 The Authors Journal compilation © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
spellingShingle Reviews
Benedikz, Eirikur
Kloskowska, Ewa
Winblad, Bengt
The rat as an animal model of Alzheimer’s disease
title The rat as an animal model of Alzheimer’s disease
title_full The rat as an animal model of Alzheimer’s disease
title_fullStr The rat as an animal model of Alzheimer’s disease
title_full_unstemmed The rat as an animal model of Alzheimer’s disease
title_short The rat as an animal model of Alzheimer’s disease
title_sort rat as an animal model of alzheimer’s disease
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496102/
https://www.ncbi.nlm.nih.gov/pubmed/19432812
http://dx.doi.org/10.1111/j.1582-4934.2009.00781.x
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