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Chemotherapy drug response in ovarian cancer cells strictly depends on a cathepsin D-Bax activation loop

The ovarian cancer cell lines A2780 (wild-type p53) and NIHOVCAR3 (mutated p53) showed, respectively, sensitivity and resistance towards several chemotherapy drugs. We hypothesized that the two cell lines differ in their ability to activate the intrinsic death pathway and have, therefore, dissected...

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Detalles Bibliográficos
Autores principales:	Castino, Roberta, Peracchio, Claudia, Salini, Alessandra, Nicotra, Giuseppina, Trincheri, Nicol F, Démoz, Marina, Valente, Guido, Isidoro, Ciro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2009
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496106/ https://www.ncbi.nlm.nih.gov/pubmed/18657225 http://dx.doi.org/10.1111/j.1582-4934.2008.00435.x

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