Cargando…

Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors

Colorectal cancer is a major health problem and the second cause of cancer related death in western countries. Signaling pathways that control tissue homeostasis are often deregulated during tumorigenesis and contribute to tumor development. Studies in mouse models have shown that the p38 MAPK pathw...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gupta, Jalaj, Igea, Ana, Papaioannou, Marilena, Lopez-Casas, Pedro Pablo, Llonch, Elisabet, Hidalgo, Manuel, Gorgoulis, Vassilis G., Nebreda, Angel R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496165/ https://www.ncbi.nlm.nih.gov/pubmed/25890501

Ejemplares similares

Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
por: Batlle, Raquel, et al.
Publicado: (2019)

Targeting of non-oncogene addiction
por: Igea, Ana, et al.
Publicado: (2015)

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK
por: Pereira, Lorena, et al.
Publicado: (2013)

Roles of p38α mitogen‐activated protein kinase in mouse models of inflammatory diseases and cancer
por: Gupta, Jalaj, et al.
Publicado: (2015)

A novel peptide that inhibits E2F transcription and regresses prostate tumor xenografts
por: Xie, Xiaoqi, et al.
Publicado: (2014)

Novel combinations of PI3K-mTOR inhibitors with dacomitinib or chemotherapy in PTEN-deficient patient-derived tumor xenografts
por: Brana, Irene, et al.
Publicado: (2017)

Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling
por: Zhu, Bing, et al.
Publicado: (2017)

Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis
por: Zur, Rafal, et al.
Publicado: (2015)

MAPK signaling control of colon cancer metastasis
por: Urosevic, Jelena, et al.
Publicado: (2014)

A ketogenic diet supplemented with medium-chain triglycerides enhances the anti-tumor and anti-angiogenic efficacy of chemotherapy on neuroblastoma xenografts in a CD1-nu mouse model
por: Aminzadeh-Gohari, Sepideh, et al.
Publicado: (2017)

The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence
por: Thompson, Keyata N., et al.
Publicado: (2015)

RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models
por: Wong, Oi Kwan, et al.
Publicado: (2018)

Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity
por: Curtis, Nicola J., et al.
Publicado: (2017)

Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types
por: Sinha, Neelam, et al.
Publicado: (2022)

Radiofrequency Ablation Remodels the Tumor Microenvironment and Promotes Neutrophil-Mediated Abscopal Immunomodulation in Pancreatic Cancer
por: Faraoni, Erika Y., et al.
Publicado: (2023)

Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302
por: Lohse, Ines, et al.
Publicado: (2016)

Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents
por: Sestak, Vit, et al.
Publicado: (2015)

Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors
por: Liu, Qinghai, et al.
Publicado: (2009)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma
por: Hayashi, Masanori, et al.
Publicado: (2017)

Age-dependent regulation of antioxidant genes by p38α MAPK in the liver
por: Pérez, Salvador, et al.
Publicado: (2018)

Myeloid p38α signaling promotes intestinal IGF‐1 production and inflammation‐associated tumorigenesis
por: Youssif, Catrin, et al.
Publicado: (2018)

Stem cell cultures derived from pediatric brain tumors accurately model the originating tumors
por: Wenger, Anna, et al.
Publicado: (2017)

Absence of ERK5/MAPK7 delays tumorigenesis in Atm(−/−) mice
por: Granados-Jaén, Alba, et al.
Publicado: (2016)

Intrinsic resistance to PIM kinase inhibition in AML through p38α-mediated feedback activation of mTOR signaling
por: Brunen, Diede, et al.
Publicado: (2016)

Stromal CD38 regulates outgrowth of primary melanoma and generation of spontaneous metastasis
por: Ben Baruch, Bar, et al.
Publicado: (2018)

CBP501 induces immunogenic tumor cell death and CD8 T cell infiltration into tumors in combination with platinum, and increases the efficacy of immune checkpoint inhibitors against tumors in mice
por: Sakakibara, Keiichi, et al.
Publicado: (2017)

Genomic profiling is predictive of response to cisplatin treatment but not to PI3K inhibition in bladder cancer patient-derived xenografts
por: Wei, Lei, et al.
Publicado: (2016)

Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells
por: Kitahata, Yuji, et al.
Publicado: (2016)

Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS
por: Woo, Chern Chiuh, et al.
Publicado: (2013)

Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition
por: Caffa, Irene, et al.
Publicado: (2015)

Regulation of Mammary Luminal Cell Fate and Tumorigenesis by p38α
por: del Barco Barrantes, Ivan, et al.
Publicado: (2017)

Tumor diversity and evolution revealed through RADseq
por: Perry, Elizabeth B., et al.
Publicado: (2017)

Exome sequencing analysis of murine medulloblastoma models identifies WDR11 as a potential tumor suppressor in Group 3 tumors
por: Wei, Lei, et al.
Publicado: (2017)

Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells
por: Fielitz, Kathrin, et al.
Publicado: (2016)

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts
por: Valletta, Simona, et al.
Publicado: (2015)

CD38 in Advanced Prostate Cancers
por: Guo, Christina, et al.
Publicado: (2021)

Sexually dimorphic tumor suppression by small mitochondrial Arf
por: van Oosterwijk, Jolieke G., et al.
Publicado: (2019)

Senescence-associated tumor growth is promoted by 12-Lipoxygenase
por: Patil, Shilpa, et al.
Publicado: (2022)

Normal tissue and tumor microenvironment adaptations to aerobic exercise enhance doxorubicin anti-tumor efficacy and ameliorate its cardiotoxicity in retired breeder mice
por: Wakefield, Zachary R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_39f6qiihg86jjg3tnefhqva4tn